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  4. Recombinant Mouse C-C motif chemokine 9 protein (Ccl9)

Recombinant Mouse C-C motif chemokine 9 protein (Ccl9)

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  • 中文名稱(chēng)：
    Recombinant Mouse C-C motif chemokine 9 protein(Ccl9) (Active)
  • 品名簡(jiǎn)稱(chēng)：
    Recombinant Mouse Ccl9 protein (Active)
  • 貨號(hào)：
    CSB-AP001281MO
  • 說(shuō)明書(shū)：
  • 規(guī)格：
    ￥852
  • 圖片：
  • 其他：

產(chǎn)品詳情

  • 純度：
    >95% as determined by SDS-PAGE.
  • 內(nèi)毒素：
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性：
    Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration range of 0.1-10 ng/ml.
  • 基因名：
    Ccl9
  • Uniprot No.：
  • 別名：
    CCF18; Ccl9; CCL9(31-101); CCL9_MOUSE; Chemokine CC motif ligand 9; Macrophage inflammatory protein 1-gamma; Macrophage inflammatory protein-related protein 2; MIP-1-gamma; MRP-2; SCYA10; SCYA9; Small inducible cytokine A9; Small-inducible cytokine A9
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Full Length of Mature Protein
  • 來(lái)源：
    E.Coli
  • 分子量：
    11.6 kDa
  • 表達(dá)區(qū)域：
    22-122aa
  • 氨基酸序列
    QITHATETKE VQSSLKAQQG LEIEMFHMGF QDSSDCCLSY NSRIQCSRFI GYFPTSGGCT RPGIIFISKR GFQVCANPSD RRVQRCIERL EQNSQPRTYK Q
  • 蛋白標(biāo)簽：
    Tag-Free
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
  • 緩沖液：
    0.2 μm filtered PBS, pH 7.4 ,lyophilized
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    5-10 business days
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Monokine with inflammatory, pyrogenic and chemokinetic properties. Circulates at high concentrations in the blood of healthy animals. Binding to a high-affinity receptor activates calcium release in neutrophils. It also inhibits colony formation of bone marrow myeloid immature progenitors.
  • 基因功能參考文獻(xiàn)：
    1. CCL9 secreted by splenic macrophages induces a CCR1dependent accumulation of MDSCs. PMID: 30365155
    2. Results show that MIP-1g promotes tumor cell growth in vitro through the activation of NFkB pathway in colorectal tumor cells. PMID: 28108624
    3. we report that chemokine CCL9 was highly induced in Gr-1(+)CD11b(+) immature myeloid cells and in premetastatic lung in tumor-bearing mice PMID: 26483204
    4. Plasmid codelivery of murine CCL19 and CCL28 enhanced Ag-specific systemic and mucosal Ab responses to HIV-1 gp140, augmented balanced Th1/Th2 responses, and increased lymphocyte subsets in various lymphoid tissues. PMID: 23858028
    5. There is protein-DNA interaction between ETV5 and Ccl9, suggesting that ETV5 might be a direct regulator of Ccl9 expression. PMID: 20799334
    6. Results reveal the potential involvement of CCL9 and CCR1 in macrophage and microglial cells by CpG-ODNs and may help understanding the role of the chemokine/chemokine receptor pairs in macrophage/microglia under physiologic and pathologic conditions. PMID: 19883904
    7. MRP-2 may be an important contributing factor in the development of atherosclerosis PMID: 12173416
    8. CCL9 and its receptor CCR1 are the major chemokine and receptor species expressed by osteoclasts, CCL9 has a role in the regulation of bone resorption PMID: 12397598
    9. An important role for CCL9 is demonstrated in the recruitment of CD11b+ dendritic cells to the dome regions of mouse Peyer's patches. PMID: 12960300
    10. MIP-1 gamma plays an important role in the differentiation & survival of osteoclasts, & bone resorption, most likely via an autocrine pathway. PMID: 15265944
    11. Keratinocyte-derived chemokine (KC) and MIP-2 alpha differ in their mediation of neutrophil function (apoptosis and chemotaxis) and contribution to the pathogenesis of lung injury following hemorrhage subsequent to sepsis. PMID: 15961314
    12. BCR/ABL repressed CCL9 expression at the transcriptional level PMID: 17160016
    13. involved in calcium mobilization and chemotaxis PMID: 11500837

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 組織特異性：
    Expressed mainly in the liver, lung, and the thymus, although some expression has been detected in a wide variety of tissues except brain.
  • 數(shù)據(jù)庫(kù)鏈接：