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CD274

CD274,即細胞程序性死亡-配體1,別名PD-L1、PDCD1 ligand 1、hPD-L1。CD274編碼的蛋白質(zhì)是一種分子量為40kDa的I型跨膜蛋白,屬于CD分子和B7家族成員。其作用機制涉及與PD-1受體結合后,傳導抑制性的信號,減低CD8+T細胞的增生,并可能通過調(diào)節(jié)Bcl-2基因控制淋巴結中抗原特異性T細胞的聚積。CD274在免疫系統(tǒng)的抑制過程中可能發(fā)揮著重要作用,例如在妊娠、組織移植、自體免疫疾病以及其他疾病如肝炎中。正常情況下,免疫系統(tǒng)對外來抗原產(chǎn)生反應,引發(fā)抗原特異性CD8+T細胞的增殖,而PD-1與CD274結合傳遞抑制信號,從而抑制CD8+T細胞的增殖。CD274的表達在多種類型的人類惡性腫瘤中具有預后意義,并在腫瘤微環(huán)境中通過抑制細胞毒性T細胞的活性為腫瘤細胞提供免疫逃逸。

熱銷產(chǎn)品

Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) (CSB-MP878942HU1)

驗證數(shù)據(jù)

CSB-MP878942HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP878942HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m,antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL.

CSB-MP878942HU1

The purity of CD274 was greater than 90% as determined by SEC-HPLC.

CD274 Recombinant Monoclonal Antibody (CSB-RA878942MA1HU)

驗證數(shù)據(jù)

CSB-RA878942MA1HU

IHC image of CSB-RA878942MA1HU diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA878942MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

CD274 Antibodies

CD274 for Homo sapiens (Human)

CD274 Proteins

CD274 Proteins for Homo sapiens (Human)

CD274 Proteins for Mus musculus (Mouse)

CD274 ELISA Kit

CD274 ELISA Kit for Homo sapiens (Human)

CD274 ELISA Kit for Mus musculus (Mouse)