EPHA3
EphA3屬于Eph受體家族的一員，被認為是細胞粘附和遷移的調節器。EphA3最初是從前B淋巴白血病細胞表面（ALL）細胞系（LK63）中分離得到的表面抗原。EphA3在大腦和脊髓，肺，腎，心臟和肌肉組織的胚胎發育的各個階段高度表達。在正常成人組織中EphA3幾乎不存在，并且在中樞神經系統（CNS）中稀疏表達，在視網膜中表達相對較高，在膀胱，前列腺，子宮和心臟中的表達較少。EphA3在胃癌、肺癌、腎癌、結腸癌、黑色素瘤、肉瘤、膽管癌、前列腺癌等實體腫瘤中異常表達，并且與腫瘤的侵襲轉移相關。EphA3的配體包括Ephrin-B2和Ephrin-A5。EphA3與配體結合，在正常細胞黏附、遷移、血管生成中發揮重要的作用，研究表明Eph受體或ephrin蛋白在維持血管、腎臟及腸道等組織的結構上發揮著一定的作用。此外，它們還和許多腫瘤血管的形成密切相關，并被認為參與腫瘤的侵襲和轉移。
Recombinant Human EPHA3 活性蛋白實驗驗證數據
SDS-PAGE
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized EPHA3 at 2 μg/ml can bind human EFNA5(CSB-MP007464HU), the EC50 of the protein is 0.9734-1.179 ng/ml.
Human EPHA3 protein his tag (CSB-MP007723HU) captured on COOH chip can bind Human EFNA5 protein Fc tag (CSB-MP007464HU) with an affinity constant of 13.8 nM as detected by LSPR Assay.
EPHA3 Antibodies
EPHA3 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA159480 | Phospho-EPHA3 (Tyr779/833) Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA030077 | EPHA3 (Ab-602) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA298527 | EPHA3 Antibody | Human | ELISA,WB |
| CSB-PA008057 | EPHA3 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA008060 | EPHA3 Antibody | Human,Mouse,Rat | WB, ELISA |
EPHA3 Proteins
EPHA3 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007723HU CSB-EP007723HU CSB-BP007723HU CSB-EP007723HU-B |
Recombinant Human Ephrin type-A receptor 3 (EPHA3), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP007723HU | Recombinant Human Ephrin type-A receptor 3 (EPHA3), partial (Active) | Mammalian cell |
EPHA3 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007723MO CSB-EP007723MO CSB-BP007723MO CSB-MP007723MO CSB-EP007723MO-B |
Recombinant Mouse Ephrin type-A receptor 3 (Epha3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EPHA3 Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007723CH CSB-EP007723CH CSB-BP007723CH CSB-MP007723CH CSB-EP007723CH-B |
Recombinant Chicken Ephrin type-A receptor 3 (EPHA3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EPHA3 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007723RA CSB-EP007723RA CSB-BP007723RA CSB-MP007723RA CSB-EP007723RA-B |
Recombinant Rat Ephrin type-A receptor 3 (Epha3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EPHA3 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007723DIL CSB-EP007723DIL CSB-BP007723DIL CSB-MP007723DIL CSB-EP007723DIL-B |
Recombinant Danio rerio Ephrin type-A receptor 3 (epha3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
