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GLP1R

GLP1R,全稱為胰高血糖素樣肽-1受體,是調(diào)節(jié)血糖的重要因子。它廣泛分布于胰島β細(xì)胞、胃、小腸、心臟、腎臟、肺等組織器官中。當(dāng)GLP1R被胰高血糖素樣肽-1(GLP-1)或人工合成的GLP-1R激動(dòng)劑激活后,能夠促進(jìn)胰島素分泌,抑制胰高血糖素分泌,減緩胃腸動(dòng)力,增加飽腹感,從而發(fā)揮多種生理功能。GLP1R蛋白也被稱為GLP-1受體的別名。近年來(lái),GLP1R受體激動(dòng)劑成為治療2型糖尿病和肥胖癥的重要藥物靶點(diǎn),如司美格魯肽、利拉魯肽等。目前,全球范圍內(nèi)已有多種GLP-1R激動(dòng)劑藥物獲批上市,為患者提供了更多的治療選擇。此外,GLP1R受體激動(dòng)劑在治療非酒精性脂肪性肝炎、阿爾茨海默病等疾病方面也展現(xiàn)出一定的潛力。隨著對(duì)GLP1R蛋白研究的深入,其作用機(jī)制和臨床應(yīng)用將得到進(jìn)一步拓展。

熱銷產(chǎn)品

Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial (Active) (CSB-MP009514HUb1)

驗(yàn)證數(shù)據(jù)

CSB-MP009514HUb1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP009514HUb1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC50 is 54.54-94.23 ng/mL.

Recombinant Mouse Glucagon-like peptide 1 receptor (Glp1r), partial (Active) (CSB-MP009514MO1)

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CSB-MP009514MO1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP009514MO1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Glp1r at 2 μg/ml can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA3HU). The EC50 is 141.7-172.4 ng/mL.

Recombinant Macaca fascicularis Glucagon-like peptide 1 receptor (GLP1R), partial (Active) (CSB-MP4826MOV)

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CSB-MP4826MOV

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP4826MOV

Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis GLP1R at 2 μg/ml can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA2HU). The EC50 is 1.292-1.518 ng/mL.

Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), patial (Active) (CSB-MP009514RA2)

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CSB-MP009514RA2

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP009514RA2

Activity
Measured by its binding ability in a functional ELISA. Immobilized Rat Glp1r at 2 μg/ml can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA2HU). The EC50 is 8.630-10.66 ng/mL.

GLP1R monoclonal antibody (CSB-RA009514MA1HU)

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CSB-RA009514MA1HU

The Binding Activity of GLP1R with anti-GLP1R antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R(CSB-MP009514HUb1) at 2 μg/mL can bind Anti-GLP1R recombinant antibody, the EC50 is 54.54-94.23 ng/mL.

CSB-RA009514MA1HU

Untransfected HEK-293T cells surface (green line) and transfected Human GLP1R HEK-293T stable cells surface (red line) were stained with anti-GLP1R antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-RA009514MA1HU

Positive WB detected in: MCF-7 whole cell lysate(30μg),Mouse Heart tissue lysate(30μg),Rat Heart tissue lysate(30μg)
All lanes: GLP1R antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa
Exposure time: 300s

GLP1R Antibody (CSB-PA009514YA01HU)

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CSB-PA009514YA01HU

Western blot
All lanes: GLP1R antibody at 12µg/ml
Lane 1: Mouse heart tissue
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa

CSB-PA009514YA01HU

Immunofluorescent analysis of 293T cells using CSB-PA009514YA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

GLP1R Antibodies

GLP1R for Homo sapiens (Human)

GLP1R for Mus musculus (Mouse)

GLP1R Proteins

GLP1R Proteins for Rattus norvegicus (Rat)

GLP1R Proteins for Mus musculus (Mouse)

GLP1R Proteins for Homo sapiens (Human)

GLP1R Proteins for Homo sapiens(Human)

GLP1R ELISA Kit

GLP1R ELISA Kit for Mus musculus (Mouse)