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ICAM1

ICAM1,全稱Intercellular adhesion molecule 1,也稱為CD54、MALA-2等,是一種重要的細(xì)胞表面糖蛋白,主要表達(dá)于內(nèi)皮細(xì)胞和免疫細(xì)胞。它通過與其他細(xì)胞表面的受體結(jié)合,參與白細(xì)胞遷移和活化過程,對免疫應(yīng)答和炎癥反應(yīng)起著關(guān)鍵作用。ICAM1還與鼻病毒等病毒入侵細(xì)胞有關(guān),并在多種疾病中發(fā)揮作用,如炎癥性腸病、甲狀腺癌、自身免疫性疾病等。近年來,針對ICAM1的藥物研發(fā)取得顯著進(jìn)展,例如德克薩斯大學(xué)MD安德森癌癥中心開發(fā)的新型CAR-T細(xì)胞療法AIC100,通過靶向ICAM1蛋白,在治療晚期甲狀腺癌方面展現(xiàn)出良好效果。此外,Ionis Pharmaceuticals Inc研發(fā)的antisense oligonucleotides ICAM-1 (Isis)也是一種ICAM1抑制劑,用于治療炎性疾病和腫瘤。這些進(jìn)展為ICAM1相關(guān)疾病的治療提供了新的希望。

熱銷產(chǎn)品

Recombinant Human Intercellular adhesion molecule 1 (ICAM1), partial (Active) (CSB-MP010949HU)

驗證數(shù)據(jù)

CSB-MP010949HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP010949HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ICAM1 at 2 μg/ml can bind Anti-ICAM1 recombinant antibody (CSB-RA010949MA1HU). The EC50 is 0.2350-0.4911 ng/mL.

ICAM1 Recombinant Monoclonal Antibody (CSB-RA162789A0HU)

驗證數(shù)據(jù)

CSB-RA162789A0HU

IHC image of CSB-RA162789A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA162789A0HU

IHC image of CSB-RA162789A0HU diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA162789A0HU

Overlay histogram showing Raji cells surface stained with CSB-RA162789A0HU (red line) at 1:50. The cells were incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1μg/1*106 cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1μg/1*106 cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human intercellular adhesion molecule 1,ICAM-1 ELISA Kit (CSB-E04574h)

驗證數(shù)據(jù)

CSB-E04574h 標(biāo)準(zhǔn)曲線

貨號:CSB-E04574h

規(guī)格:96T/48T

靈敏度:0.195 ng/mL

檢測范圍:0.78 ng/mL-50 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ICAM1 Antibodies

ICAM1 for Homo sapiens (Human)

ICAM1 Proteins

ICAM1 Proteins for Rattus norvegicus (Rat)

ICAM1 Proteins for Mus musculus (Mouse)

ICAM1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

ICAM1 Proteins for Homo sapiens (Human)

ICAM1 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)

ICAM1 Proteins for Bos taurus (Bovine)

ICAM1 Proteins for Pan troglodytes (Chimpanzee)

ICAM1 Proteins for Gorilla gorilla gorilla (Lowland gorilla)

ICAM1 Proteins for Macaca mulatta (Rhesus macaque)

ICAM1 ELISA Kit

ICAM1 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)

ICAM1 ELISA Kit for Homo sapiens (Human)

ICAM1 ELISA Kit for Mus musculus (Mouse)

ICAM1 ELISA Kit for Rattus norvegicus (Rat)