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PDGFRB

PDGFRB,全稱血小板衍生生長(zhǎng)因子受體β(platelet-derived growth factor receptor beta),是一種重要的細(xì)胞表面受體蛋白。它也被稱為CD140b、JTK12、PDGFR1等多種別名。PDGFRB與PDGFRA(CD140a)同屬于受體酪氨酸激酶III亞家族,共同參與血小板衍生生長(zhǎng)因子的信號(hào)轉(zhuǎn)導(dǎo)過(guò)程。PDGFRB能夠與PDGF-BB和PDGF-AB異構(gòu)體高親和力結(jié)合,而PDGFRA則能結(jié)合PDGF的三個(gè)異構(gòu)體。PDGFRB在多種細(xì)胞類型中發(fā)揮重要作用,參與血管發(fā)育、細(xì)胞增殖、遷移等過(guò)程。PDGFRB的異常激活與多種疾病的發(fā)生發(fā)展密切相關(guān),包括癌癥、心血管疾病和基底神經(jīng)節(jié)鈣化等。目前,針對(duì)PDGFRB的藥物研發(fā)已成為熱點(diǎn),多種靶向藥物已進(jìn)入臨床試驗(yàn)階段,為相關(guān)疾病的治療提供了新的選擇。

熱銷產(chǎn)品

Recombinant Human Platelet-derived growth factor receptor beta (PDGFRB), partial (Active) (CSB-MP017713HU1)

驗(yàn)證數(shù)據(jù)

CSB-MP017713HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP017713HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human PDGFRB at 2 μg/ml can bind Anti-PDGFRB recombinant antibody (CSB-RA017713MA1HU). The EC50 is 2.471-2.776 ng/mL.

CSB-MP017713HU1

The purity of PDGFRB was greater than 95% as determined by SEC-HPLC

Recombinant Human Platelet-derived growth factor receptor beta (PDGFRB), partial (CSB-EP017713HU)

驗(yàn)證數(shù)據(jù)

CSB-EP017713HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PDGFRB Recombinant Monoclonal Antibody (CSB-RA213932A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA213932A0HU

IHC image of CSB-RA213932A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

PDGFRB Antibodies

PDGFRB for Homo sapiens (Human)

PDGFRB Proteins

PDGFRB Proteins for Mus musculus (Mouse)

PDGFRB Proteins for Homo sapiens (Human)

PDGFRB Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)

PDGFRB Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

PDGFRB ELISA Kit

PDGFRB ELISA Kit for Homo sapiens (Human)

PDGFRB ELISA Kit for Mus musculus (Mouse)