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Your Good Partner in Biology Research

SELE

SELE,即E選擇素,它是一種細胞表面糖蛋白,由SELE基因編碼,主要表達在活化的內皮細胞上。SELE的作用機制涉及其在炎癥反應中的調節作用,特別是在白細胞與內皮細胞的粘附過程中。當內皮細胞受到炎癥介質如腫瘤壞死因子α(TNF-α)或IL-1等刺激時,SELE表達上調,促進滾動的白細胞粘附于內皮細胞表面,并進一步遷移至炎癥部位。SELE的信號通路包括與白細胞表面的配體如sialyl-Lewis X(sLe^X)相互作用,觸發細胞內信號傳導,增強細胞間的粘附。在生物學意義上,SELE對調控免疫細胞的遷移、參與炎癥反應和免疫監視等過程至關重要。SELE的異常表達與多種病理過程有關,包括動脈粥樣硬化、炎癥性腸病和自身免疫性疾病等。

熱銷產品

Recombinant Pig E-selectin (SELE), partial (CSB-EP020975PIe1)

驗證數據

CSB-EP020975PIe1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SELE Antibody (CSB-PA056380)

驗證數據

CSB-PA056380

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA056380(SELE Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA056380

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA056380(SELE Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)

SELE Antibodies

SELE for Homo sapiens (Human)

SELE for Pig

SELE Proteins

SELE Proteins for Sus scrofa (Pig)

SELE Proteins for Bos taurus (Bovine)

SELE Proteins for Homo sapiens (Human)

SELE Proteins for Oryctolagus cuniculus (Rabbit)

SELE Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

SELE Proteins for Equus caballus (Horse)

SELE ELISA Kit

SELE ELISA Kit for Homo sapiens (Human)

SELE ELISA Kit for Mus musculus (Mouse)

SELE ELISA Kit for Rattus norvegicus (Rat)