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TFRC

TFRC,全稱轉(zhuǎn)鐵蛋白受體1,也被稱為CD71、TFR1、p90。該蛋白在細(xì)胞表面以同源二聚體的形式存在,對(duì)細(xì)胞生長(zhǎng)至關(guān)重要。TFRC的主要功能是促進(jìn)細(xì)胞鐵的吸收,通過(guò)受體介導(dǎo)的內(nèi)吞作用將鐵離子從轉(zhuǎn)鐵蛋白中釋放到細(xì)胞內(nèi),從而維持細(xì)胞內(nèi)鐵穩(wěn)態(tài)。TFRC在多種腫瘤中高表達(dá),并且與腫瘤的發(fā)生、侵襲和轉(zhuǎn)移有關(guān),是一種重要的癌基因。其表達(dá)程度與疾病的惡性程度相關(guān),過(guò)表達(dá)可促進(jìn)腫瘤細(xì)胞生長(zhǎng)、增殖和轉(zhuǎn)移,因此成為開(kāi)發(fā)抗體偶聯(lián)藥物的新靶點(diǎn)。目前,全球已有多款針對(duì)TFRC的藥物進(jìn)入臨床試驗(yàn)階段,藥物類型涉及單抗、雙抗、融合蛋白、ADC等,其中Avidity的AOC-1001是全球首款A(yù)OC藥物,已進(jìn)入臨床二期。此外,TFRC還參與了T細(xì)胞的激活過(guò)程,為T(mén)細(xì)胞的激活提供了所需的第二刺激信號(hào),抗TFR1抗體有望成為研究淋巴細(xì)胞活化的一種新的高選擇性探針。

熱銷產(chǎn)品

Recombinant Human Transferrin receptor protein 1 (TFRC), partial (Active) (CSB-MP3648HU)

驗(yàn)證數(shù)據(jù)

CSB-MP3648HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP3648HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TFRC at 2μg/mL can bind Anti-TFRC recombinant antibody (CSB-RA023441MA1HU), the EC50 is 3.305-8.220 ng/mL.

CSB-MP3648HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TFRC at 2 μg/ml can bind Human TF (CSB-MP023412HU). The EC50 is 33.20-40.09 ng/mL.

CSB-MP3648HU

TFRC Recombinant Monoclonal Antibody (CSB-RA023441MA1HU) captured on Protein A Chip can bind Recombinant Human TFRC protein with an affinity constant of 0.117 nM as detected by MetaSPR Assay (WeSPRTM 200).

TFRC Antibody (CSB-PA07219A0Rb)

驗(yàn)證數(shù)據(jù)

CSB-PA07219A0Rb

Western Blot
Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, PC-3 whole cell lysate, HEK293 whole cell lysate, MCF7 whole cell lysate
All lanes: TFRC antibody at 1:5000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 85 kDa
Observed band size: 85 kDa

CSB-PA07219A0Rb

IHC image of CSB-PA07219A0Rb diluted at 1:150 and staining in paraffin-embedded Human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-PA07219A0Rb

IHC image of CSB-PA07219A0Rb diluted at 1:150 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-PA07219A0Rb

Immunofluorescence staining of HepG2 cell with CSB-PA07219A0Rb at 1:15, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-PA07219A0Rb

Immunofluorescence staining of HepG2 cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human soluble transferrin receptor,sTfR ELISA Kit (CSB-E09100h)

驗(yàn)證數(shù)據(jù)

CSB-E09100h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E09100h

規(guī)格:96T/48T

靈敏度:Request Information

檢測(cè)范圍:Request Information

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

TFRC Antibodies

TFRC for Homo sapiens (Human)

TFRC Proteins

TFRC Proteins for Equus caballus (Horse)

TFRC Proteins for Pongo abelii (Sumatran orangutan)

TFRC Proteins for Mus musculus (Mouse)

TFRC Proteins for Sus scrofa (Pig)

TFRC Proteins for Gallus gallus (Chicken)

TFRC Proteins for Rattus norvegicus (Rat)

TFRC Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

TFRC Proteins for Felis catus (Cat) (Felis silvestris catus)

TFRC Proteins for Mus musculus(Mouse)

TFRC Proteins for Homo sapiens (Human)

TFRC ELISA Kit

TFRC ELISA Kit for Mus musculus (Mouse)

TFRC ELISA Kit for Homo sapiens (Human)