TNFSF11

TNFSF11，即腫瘤壞死因子超家族成員11，別名OPGL、RANKL、TRANCE，是一種關(guān)鍵的細(xì)胞因子，在骨代謝、免疫系統(tǒng)和腫瘤生物學(xué)中扮演重要角色。由T細(xì)胞產(chǎn)生，TNFSF11通過(guò)與其受體RANK結(jié)合，激活NF-κB信號(hào)通路，促進(jìn)破骨細(xì)胞的分化和活性，影響骨吸收。異常的TNFSF11表達(dá)與骨質(zhì)疏松癥、骨轉(zhuǎn)移癌等疾病有關(guān)，同時(shí)在腫瘤微環(huán)境中可能促進(jìn)腫瘤細(xì)胞的侵襲和轉(zhuǎn)移，使其成為治療相關(guān)疾病的潛在靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Tumor necrosis factor ligand superfamily member 11 (TNFSF11), partial (Active) (CSB-MP023986HU(F2))

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF11 at 2 μg/ml can bind Human TNFRSF11B (CSB-MP023969HU). The EC₅₀ is 4.514-5.152 ng/mL.

TNFSF11 Antibody (CSB-PA023986LA01HU)

驗(yàn)證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA023986LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA023986LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA023986LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

TNFSF11 Antibody

TNFSF11 Protein

TNFSF11 ELISA Kit

TNFSF11 Antibodies

TNFSF11 for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA07964A0Rb	Tnfsf11 Antibody	Mouse	ELISA
CSB-PA07964C0Rb	Tnfsf11 Antibody, FITC conjugated	Mouse
CSB-PA07964D0Rb	Tnfsf11 Antibody, Biotin conjugated	Mouse	ELISA
CSB-PA023986LA01MO	Tnfsf11 Antibody	Mouse	ELISA, IF
CSB-PA023986LB01MO	Tnfsf11 Antibody, HRP conjugated	Mouse	ELISA
CSB-PA023986LC01MO	Tnfsf11 Antibody, FITC conjugated	Mouse
CSB-PA023986LD01MO	Tnfsf11 Antibody, Biotin conjugated	Mouse	ELISA

TNFSF11 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA111246	TNFSF11 Antibody	Human,Mouse	ELISA,WB,IF
CSB-PA003937	TNFSF11 Antibody	Human,Mouse,Rat	WB, IF, ELISA
CSB-PA005647	TNFSF11 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA023986LA01HU	TNFSF11 Antibody	Human	ELISA, IHC, IF
CSB-PA023986LB01HU	TNFSF11 Antibody, HRP conjugated	Human	ELISA
CSB-PA023986LC01HU	TNFSF11 Antibody, FITC conjugated	Human
CSB-PA023986LD01HU	TNFSF11 Antibody, Biotin conjugated	Human	ELISA

TNFSF11 Proteins

TNFSF11 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP023986MO CSB-BP023986MO CSB-MP023986MO CSB-EP023986MO-B	Recombinant Mouse Tumor necrosis factor ligand superfamily member 11 (Tnfsf11), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP023986MO	Recombinant Mouse Tumor necrosis factor ligand superfamily member 11 (Tnfsf11), partial	E.coli
CSB-CF023986MO(A4)	Recombinant Mouse Tumor necrosis factor ligand superfamily member 11 (Tnfsf11)	in vitro E.coli expression system
CSB-AP005021MO	Recombinant Mouse Tumor necrosis factor ligand superfamily member 11 (Tnfsf11), partial (Active)	Mammalian

TNFSF11 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP023986HU1 CSB-EP023986HU1 CSB-BP023986HU1 CSB-MP023986HU1 CSB-EP023986HU1-B	Recombinant Human Tumor necrosis factor ligand superfamily member 11 (TNFSF11), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF023986HU	Recombinant Human Tumor necrosis factor ligand superfamily member 11 (TNFSF11)	in vitro E.coli expression system
CSB-AP004851HU	Recombinant Human Tumor necrosis factor ligand superfamily member 11 (TNFSF11), partial (Active)	E.coli
CSB-MP023986HU(F2)	Recombinant Human Tumor necrosis factor ligand superfamily member 11 (TNFSF11), partial (Active)	Mammalian cell
CSB-MP023986HU(F2)b0	Recombinant Human Tumor necrosis factor ligand superfamily member 11 (TNFSF11), partial	Mammalian cell

TNFSF11 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP880653RA CSB-EP880653RA CSB-BP880653RA CSB-MP880653RA CSB-EP880653RA-B	Recombinant Rat Tumor necrosis factor ligand superfamily member 11 (Tnfsf11), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TNFSF11 ELISA Kit

TNFSF11 ELISA Kit for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	樣本類型	靈敏度
CSB-E05125h	Human soluble receptor activator of nuclear factor-kB ligand,sRANKL ELISA Kit	serum, plasma, cell culture supeernates, tissue homogenates	1.95 pg/mL