Recombinant Human C-X-C motif chemokine 17 protein (CXCL17) (Active)
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中文名稱(chēng):Recombinant Human C-X-C motif chemokine 17 protein(CXCL17) (Active)
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品名簡(jiǎn)稱(chēng):Recombinant Human CXCL17 protein (Active)
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貨號(hào):CSB-AP000781HU
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說(shuō)明書(shū):
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規(guī)格:¥852
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圖片:
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其他:
產(chǎn)品詳情
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純度:>96% as determined by SDS-PAGE.
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內(nèi)毒素:Less than 1.0 EU/μg as determined by LAL method.
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生物活性:Fully biologically active when compared to standard. The ED50 as determined by its ability to induce VEGF expression using murine endothelial cells is less than 5.0 μg/ml, corresponding to a specific activity of >200 IU/mg.
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基因名:CXCL17
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Uniprot No.:
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別名:CXCL17; VCC1; UNQ473/PRO842C-X-C motif chemokine 17; 6-Cys CXCL17; Dendritic cell and monocyte chemokine-like protein; DMC; VEGF coregulated chemokine 1) [Cleaved into: 4-Cys CXCL17]
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種屬:Homo sapiens (Human)
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蛋白長(zhǎng)度:Full Length of Mature Protein
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來(lái)源:E.Coli
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分子量:11.5 kDa
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表達(dá)區(qū)域:22-119aa
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氨基酸序列SSLNPGVARG HRDRGQASRR WLQEGGQECE CKDWFLRAPR RKFMTVSGLP KKQCPCDHFK GNVKKTRHQR HHRKPNKHSR ACQQFLKQCQ LRSFALPL
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蛋白標(biāo)簽:Tag-Free
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產(chǎn)品提供形式:Liquid or Lyophilized powder
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緩沖液:Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4, with 3 % Trehalose.
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儲(chǔ)存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質(zhì)期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:5-10 business days
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Datasheet & COA:Please contact us to get it.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections. Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions.; seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.
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基因功能參考文獻(xiàn):
- High Lymph node CXCL17 messenger RNA is associated with colon cancer. PMID: 30198422
- High expression of CXCL17 correlates with shorter overall survival of breast cancer patients.CXCL17 interacts with CXCR8 in breast cancer cells. PMID: 28943434
- CXCL17 attenuates Imiquimod -induced psoriasis-like skin inflammation by recruiting myeloid-derived suppressor cells and regulatory T cells , which may be important for regulating excessive inflammation in psoriasis skin. PMID: 28389593
- This article shows that GPR35 is the receptor of CXCL17. PMID: 25411203
- CXCL17 production correlated with adverse immune infiltration and might be an important target for anti-HCC therapies. PMID: 25303284
- We conclude that CXCL17 is an antimicrobial mucosal chemokine that may play a role in the pathogenesis of interstitial lung diseases PMID: 22611239
- these results suggest that VCC-1 is involved in cisplatin-induced apoptosis of HepG2 cells, and also provides some evidence for VCC-1 as a potential cellular target for chemotherapy. PMID: 22425983
- An Fc-fusion protein of 35kDa with a modified human immunoglobulin IgG1 Fc domain is capable of inhibiting CC chemokine-induced calcium flux, chemotaxis, and beta-arrestin recruitment in primary macrophages and transfected cells. PMID: 21586597
- Immune surveillance occurs during the early intraepithelial stages of human pancreatic carcinogenesis and is mediated by expression of CXCL17 and ICAM2. PMID: 20955708
- DMC induces migration of monocytes and immature dendritic cells. Expression studies show that DMC is constitutively expressed in lung, suggesting a potential role for DMC in recruiting monocytes and dendritic cells from blood into lung parenchyma PMID: 16455961
- VCC1 plays a role in angiogenesis and possibly in the development of tumors in some tissue types PMID: 16989774
- These results strongly suggest that VCC-1 plays an important role in hepatocellular carcinoma cell invasion and tumor growth. PMID: 19657564
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亞細(xì)胞定位:Secreted.
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蛋白家族:Intercrine alpha (chemokine CxC) family
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組織特異性:Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.
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