Recombinant Mouse Lymphotactin protein (Xcl1) (Active)
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中文名稱(chēng):小鼠Xcl1重組蛋白
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品名簡(jiǎn)稱(chēng):Recombinant Mouse Xcl1 protein (Active)
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貨號(hào):CSB-AP001201MO
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說(shuō)明書(shū):
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規(guī)格:¥852
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圖片:
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其他:
產(chǎn)品詳情
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純度:>97% as determined by SDS-PAGE.
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內(nèi)毒素:Less than 1.0 EU/μg as determined by LAL method.
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生物活性:Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human XCR1 transfected murine BaF3 cells is less than 100 ng/ml, corresponding to a specific activity of >1.0x104 IU/mg.
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基因名:
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Uniprot No.:
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別名:Xcl1; Lptn; Ltn; Scyc1; Lymphotactin; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; Small-inducible cytokine C1
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種屬:Mus musculus (Mouse)
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蛋白長(zhǎng)度:Full Length of Mature Protein
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來(lái)源:E.Coli
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分子量:10.1 kDa
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表達(dá)區(qū)域:22-114aa
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氨基酸序列VGTEVLEESS CVNLQTQRLP VQKIKTYIIW EGAMRAVIFV TKRGLKICAD PEAKWVKAAI KTVDGRASTR KNMAETVPTG AQRSTSTAIT LTG
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蛋白標(biāo)簽:Tag-Free
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產(chǎn)品提供形式:Liquid or Lyophilized powder
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緩沖液:0.2 μm filtered PBS, pH 7.4 ,lyophilized
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儲(chǔ)存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質(zhì)期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:5-10 business days
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Datasheet & COA:Please contact us to get it.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.
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基因功能參考文獻(xiàn):
- study provides in vitro and in vivo evidence that the interaction between XCL1 and alpha9 integrin has an important role for autoimmune diseases PMID: 28550205
- The interaction between XCL1 and XCR1 plays a crucial role in the classical immunology response. PMID: 27387353
- Data show that mice lacking either XCL1 or XCR1 exhibit similar specific defects in intestinal T cell populations as XCR1-dendritic cells (DC)-deficient mice. Therefore it is possible that the XCR1-XCL1 axis itself is directly involved in intestinal T cell homeostasis, via a mechanism that might either involve interaction with XCR1+ DCs or be independent of this pathway. PMID: 27005831
- T inflammatory memory CD8 T cells participate to antiviral response and generate secondary memory cells with an advantage in XCL1 production PMID: 22528127
- XCL1-mediated accumulation of dendritic cells in the thymic medulla contributes to naturally occurring regulatory T cell development and is regulated by Aire. PMID: 21300913
- Data report the identification of a new stable molecular assembly formed between the ATAC and Mediator complexes in mouse embryonic stem cells. PMID: 20508642
- The expression patterns of XCR1 and XCL1 were conserved in human and mice blood cells, including certain dendritic cell subsets. PMID: 20541533
- MIP-1alpha, MIP-1beta, RANTES, and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokines. PMID: 11972057
- Adenovirus-mediated intratumoral Lptn gene transfer potentiates the antibody-targeted superantigen therapy of experimental melanoma. PMID: 12226740
- In a brain-targeted HIV-1 Tat transgenic model, Tat expression up-regulates XCL1 production not only in Tat-expressing murine astrocytes, but also in monocytes and macrophages/microglia. PMID: 14734774
- Lymphotactin gene-modified dendritoma induces T-cell proliferation and strong cytotoxic T lymphocytes reaction against allogenic hepatocellular carcinoma cells. PMID: 17990361
- Results describe the role of XCL1 during the course of the immune response to pulmonary M. tuberculosis infection. PMID: 19097989
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亞細(xì)胞定位:Secreted.
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蛋白家族:Intercrine gamma family
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組織特異性:Expressed in activated CD8(+) T cells. In the thymus, expressed by medullary thymic epithelial cells.
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