Rat adrenocorticotropic hormone (ACTH) ELISA kit

Rat adrenocorticotropic hormone (ACTH) ELISA kit

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中文名稱：

大鼠促腎上腺皮質(zhì)激素(ACTH)酶聯(lián)免疫試劑盒
貨號：

CSB-E06875r
規(guī)格：

96T/48T
價(jià)格：

￥3900/￥2500
其他：

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產(chǎn)品描述：

大鼠促腎上腺皮質(zhì)激素(ACTH)酶聯(lián)免疫試劑盒（CSB-E06875r）為競爭法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的ACTH含量。促腎上腺皮質(zhì)激素（ACTH）是腺垂體分泌的調(diào)節(jié)腎上腺皮質(zhì)活動的重要激素。其分泌受下丘腦促腎上腺皮質(zhì)激素釋放激素調(diào)控。研究機(jī)制方面，它作用于腎上腺皮質(zhì)，刺激皮質(zhì)醇等糖皮質(zhì)激素合成與分泌，在應(yīng)激反應(yīng)、代謝調(diào)節(jié)等生理過程中發(fā)揮關(guān)鍵作用。試劑盒檢測范圍為1.25 pg/mL-50 pg/mL，適用于評估實(shí)驗(yàn)大鼠應(yīng)激狀態(tài)下的激素水平變化、腎上腺皮質(zhì)功能研究及藥物干預(yù)對神經(jīng)內(nèi)分泌系統(tǒng)的影響本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
縮寫：

ACTH
種屬：

Rattus norvegicus (Rat)
樣本類型：

serum, plasma, tissue homogenates
檢測范圍：

1.25 pg/mL-50 pg/mL
靈敏度：

1.25 pg/mL
反應(yīng)時(shí)間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領(lǐng)域：

Metabolism
測定原理：

quantitative
測定方法：

Competitive

精密度：

線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of rat ACTH in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:1	Average %	95
	Range %	90-99
1:2	Average %	96
	Range %	91-102
1:4	Average %	86
	Range %	82-94
1:8	Average %	89
	Range %	82-96

回收率：

The recovery of rat ACTH spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	90	86-96
EDTA plasma (n=4)	101	97-105

標(biāo)準(zhǔn)曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

pg/ml	OD1	OD2	Average
50	0.341	0.340	0.341
25	0.476	0.474	0.475
11.5	0.700	0.713	0.707
3.75	1.056	1.067	1.062
1.25	1.468	1.387	1.428
0	1.945	1.864	1.905

數(shù)據(jù)處理：

ELISA操作視頻及標(biāo)曲繪制軟件下載
貨期：

3-5 working days

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Estrogen re-enhanced prenatal stress-related visceral sensitization and pain regulation J Chen,Research Square,2020
The Involvement of Notch1 Signaling Pathway in Mid-aged Female Rats under Chronic Restraint Stress J Shen,Neuroscience Letters,2020
Saponin extract of Baihe-Zhimu Tang ameliorates depression in chronic mild stress rats D Jia,Journal of Functional Foods,2020
Vitamin D3 attenuates anxiety-like behavior in long-term ovariectomized rats with unpredictable mild stress BARANENKO D,BIOCELL,2019
Metabolomic signatures and microbial community profiling of depressive rat model induced by adrenocorticotrophic hormone Song J, et al,Journal of Translational Medicine,2019
The Effects of High Peripubertal Caffeine Exposure on the Adrenal Gland in Immature Male and Female Rats Ryu KY,Nutrients,2019
Chronic paradoxical sleep deprivation-induced depression Ma W, et al,Life Sciences,2019
Exposure to cell phone radiofrequency changes corticotrophin hormone levels and histology of the brain and adrenal glands in male Wistar rat Sima Shahabi.et al,Iranian Journal of Basic Medical Sciences,2018
Social defeat stress before pregnancy induces depressive-like behaviours and cognitive deficits in adult male offspring: correlation with neurobiological changes Wei S.et al,BMC Neuroscience,2018
Transplantation of bone marrow mesenchymal stem cells reduces GluR1 expression in the hippocampus and amygdala and affects secretion of stress-related hormones in rats with spinal cord injuries: a potential anti-chronic stress mechanism Jia-Jia Sun.et al,INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2018
Perfluorooctane sulfonate (PFOS) can alter the hypothalamic?pituitary?adrenal (HPA) axis activity by modifying CRF1 and glucocorticoid receptors R. Salgado.et al,Toxicology Letters,2018
Sini Decoction improves adrenal function and the short-term outcome of septic rats through downregulation of adrenal Toll-like receptor 4 expression Fang Lai.et al,/,2018
A urinary metabolomics (GC-MS) strategy to evaluate the antidepressant-like effect of chlorogenic acid in adrenocorticotropic hormone-treated rats Le Zhao.et al, RSC Adv,2018
Assessment of the role of intracranial hypertension and stress on hippocampal cell apoptosis and hypothalamic-pituitary dysfunction after TBI Tan H.et al,Sci Rep,2017
Etomidate increases mortality in septic rats through inhibition of nuclear factor kappa-B rather than by causing adrenal insufficiency. Zhang Y.et al,J Surg Res.,2015
High-Cholesterol Diet Disrupts the Levels of Hormones Derived from Anterior Pituitary Basophilic Cells Yang J.et al,J Neuroendocrinol.,2016
Regulation of corticosterone secretion is modified by PFOS exposure at different levels of the hypothalamic-pituitary-adrenal axis in adult male rats Pereiro N et al,Toxicol Lett,2014
Effects of simultaneous combined exposure to CDMA and WCDMA electromagnetic fields on serum hormone levels in rats Jin YB et al,J Radiat Res,2012

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最新研究進(jìn)展：

促腎上腺皮質(zhì)激素（ACTH）是由下丘腦-垂體-腎上腺（HPA）軸分泌的激素，對于調(diào)節(jié)腎上腺皮質(zhì)激素的合成和分泌具有重要作用。以下是最近一些關(guān)于ACTH的研究進(jìn)展：
ACTH在應(yīng)激反應(yīng)中的作用：ACTH參與了應(yīng)激反應(yīng)的調(diào)節(jié)。最近的研究表明，應(yīng)激可以影響下丘腦的神經(jīng)元活動，導(dǎo)致ACTH的分泌增加。而ACTH又可以刺激腎上腺皮質(zhì)激素的合成和分泌，從而調(diào)節(jié)機(jī)體的應(yīng)激反應(yīng)。因此，ACTH也被廣泛應(yīng)用于應(yīng)激相關(guān)疾病的治療。

ACTH在自身免疫性皮膚病中的作用：ACTH具有抗炎作用，已被廣泛用于治療自身免疫性皮膚病，如銀屑病和天皰瘡等。最近的研究表明，ACTH治療不僅可以減輕癥狀，還可以改善患者的生活質(zhì)量。

ACTH在兒童癲癇中的應(yīng)用：ACTH在兒童癲癇治療中也有廣泛應(yīng)用。最近的研究表明，ACTH治療可以顯著降低癲癇持續(xù)時(shí)間和頻率，同時(shí)改善兒童的認(rèn)知和行為表現(xiàn)。

ACTH在腎上腺皮質(zhì)功能不足癥中的應(yīng)用：ACTH也被用于治療腎上腺皮質(zhì)功能不足癥，如原發(fā)性腎上腺皮質(zhì)功能不足和副腎上腺皮質(zhì)功能不足等。最近的研究表明，ACTH治療可以有效改善患者的癥狀和生活質(zhì)量。

Intra-assay Precision (Precision within an assay): CV%<15%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<15%

Three samples of known concentration were tested in twenty assays to assess.