ABCC9 Antibody
-
中文名稱：ABCC9兔多克隆抗體
-
貨號：CSB-PA043862
-
規格：￥1100
-
圖片：
-
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA043862(ABCC9 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA043862(ABCC9 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
-
-
其他：
產品詳情
-
Uniprot No.：
-
基因名：
-
別名：ABC37 antibody; abcC9 antibody; ABCC9_HUMAN antibody; AI414027 antibody; AI449286 antibody; ATFB12 antibody; ATP-binding cassette sub-family C member 9 antibody; ATP-binding cassette transporter sub-family C member 9 antibody; ATP-binding cassette; sub-family C (CFTR/MRP); member 9 antibody; CANTU antibody; CMD1O antibody; FLJ36852 antibody; Sulfonylurea receptor 2 antibody; Sulfonylurea-binding protein 2 antibody; SUR2 antibody; SUR2A antibody; SUR2B antibody
-
宿主：Rabbit
-
反應種屬：Human,Mouse,Rat
-
免疫原：Synthetic peptide of Human ABCC9
-
免疫原種屬：Homo sapiens (Human)
-
標記方式：Non-conjugated
-
抗體亞型：IgG
-
純化方式：Antigen affinity purification
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
-
產品提供形式：Liquid
-
應用范圍：ELISA,IHC
-
推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:25-1:100 -
Protocols：
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
-
功能：Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
-
基因功能參考文獻：
- Significant gene-based association between the ABCC9 gene and hippocampal sclerosis-aging appeared to be driven by a region in which a significant haplotype-based association. PMID: 28131462
- ABCC9 gene has been associated with Dilated Cardiomyopathy. 3 pathogenic variants have been associated with DCM: 1 missense -CM1410876-, 1 nonsense -CM040975-, and 1 small indel -CX041212. PMID: 27736720
- Analysis of three Cantu syndrome-associated gain of function mutations indicates that all lead to overactive K(ATP) channels, but at least two mechanisms underlie the observed gain of function: decreased ATP inhibition and enhanced MgADP activation. PMID: 26621776
- The patient reported here gives further evidence that these syndromes are an expression of the ABCC9-related disorders, ranging from hypertrichosis and acromegaloid facies to the severe end of Cantu syndrome. PMID: 26871653
- ABCC9 polymorphism associated with Brain disorders: sleep problems. depression and HS-Aging. PMID: 26226329
- single amino acid difference can account for the markedly different diazoxide sensitivities between channels containing either the SUR1 or SUR2A subunit isoforms. PMID: 26181369
- We describe novel ABCC9 variants in human brain, corresponding to altered 3'UTR length, which could lead to targeting by miR-30c PMID: 26115089
- Results show that a polymorphism in ABCC9 is associated with aging pathology, and exposure to sulfonylurea drugs is associated with increased risk for aging pathology among individuals who died age 85 and older PMID: 24770881
- This study confirmed that specific ABCC9 single-nucleotide polymorphisms is associated with HS-Aging pathology in the Alzheimer disease. PMID: 25470345
- ABCC9 is a susceptibility gene for early repolarization syndrome and Brugada syndrome. PMID: 24439875
- A mutation (V734I) in ABCC9 increases susceptibility to coronary spasm and acute myocardial infarction. PMID: 23739550
- two different de novo missense mutations in the two patients with coarse facial features and hypertrichosis PMID: 23307537
- This study showed that variants in the SUR2 gene (ABCC9) associate with epidemiological variation in human sleep duration, which is also influenced by inter-individual differences in seasonal adaptation and chronotype. PMID: 22105623
- Electrophysiological experiments show that mutations in ABCC9, associated with Cantu syndrome, reduce the ATP-mediated potassium channel inhibition, resulting in channel opening. PMID: 22610116
- Cantu syndrome is caused by mutations in ABCC9 PMID: 22608503
- mammalian oocytes express K(ATP) channels. Real-time PCR revealed that mRNA for Kir6.1, Kir6.2, SUR2A and SUR2B, were present in human oocytes of different stages. PMID: 20847183
- sequence variants in ABCC9 is unlikely to contribute to variation in postural change in systolic blood pressure PMID: 19952277
- These findings suggest that abnormal localization of the SUR2A K(+) channel protein leads to reduced K(ATP) channel activity in familial hypokalemic periodic paralysis. PMID: 19962959
- Assembly limits the pharmacological complexity of ATP-sensitive potassium channels PMID: 11825905
- down-regulation of this channel may facilitate myometrial function during late pregnancy PMID: 12356945
- In corporal smooth muscle is composed of Kir6.1-Kir6.2 construct expressed with SUR2B.K(ATP) channel in corporal smooth muscle cells is composed of heteromultimers of Kir6.1 and Kir6.2 with the ratio of 3 : 1 or 4 : 0 and SUR2B. PMID: 12934053
- role of mutation in human dilated cardiomyopathy and effect on KATP channel gating PMID: 15034580
- Syn-1A binds both NBFs of SUR1 and SUR2A but appears to exhibit distinct interactions with NBF2 of these SUR proteins in modulating the KATP channels in islet beta cells and cardiac myocytes PMID: 15339904
- newly discovered 734Ile allele in ABCC9 might influence susceptibility to precocious myocardial infarct in our population PMID: 16563363
- Syntaxin-1A actions on sulfonylurea receptor 2A blocks acidic pH-induced cardiac K(ATP) channel activation PMID: 16672225
- Results describe a new function of the Kir6.1-SUR2A complex, namely the regulation of paracellular permeability through tight junctions. PMID: 16820413
- review the structure and function of ABC proteins and discuss SUR, its regulation of the K(ATP) channel, and its role in cardiovascular disease. PMID: 18239147
- caveolin-dependent internalization is involved in PKC-epsilon-mediated inhibition of vascular K(ATP) channels (Kir6.1 and SUR2B) by phorbol 12-myristate 13-acetate or angiotensin II PMID: 18663158
- Kir6.1/SUR2B is the major functional K(ATP) channel complex in the pig MMA and MCA, and mRNA expression studies suggest that the human MMA shares this K(ATP) channel subunit profile PMID: 18996111
- caveolin-3 negatively regulates Kir6.2/SUR2A channel function. PMID: 19481058
顯示更多
收起更多
-
相關疾病：Cardiomyopathy, dilated 1O (CMD1O); Atrial fibrillation, familial, 12 (ATFB12); Hypertrichotic osteochondrodysplasia (HTOCD)
-
亞細胞定位：Membrane; Multi-pass membrane protein.
-
蛋白家族：ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
-
數據庫鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
