DAZ2 Antibody

說明書

中文名稱：

DAZ2兔多克隆抗體
貨號：

CSB-PA623785ESR1HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA623785ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA623785ESR1HU at dilution of 1:100
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DAZ2 Polyclonal antibody
Uniprot No.：

Q13117
基因名：

DAZ2
別名：

DAZ2 antibody; DAZ2_HUMAN antibody; DAZ3 antibody; Deleted in azoospermia 2 antibody; Deleted in azoospermia protein 2 antibody; Deleted in azoospermia protein 3 antibody; MGC126442 antibody; pDP1678 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Deleted in azoospermia protein 2 protein (1-200AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
基因功能參考文獻：
1. study reported a new type of AZFc deletion (gr/gr-DAZ2-DAZ4-CDY1b) and hypothesis that this new deletion is the result of 2 successive events favored by the unstable structure of AZFc region; also demonstrated that this deletion constitutes a relative high-risk factor for male infertility in Tunisian population PMID: 27457284
2. There appears to be an asociation of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population. PMID: 23512232
3. Deletion of DAZ2 and DAZ4 gene copies is associated with male infertility. PMID: 24878370
4. DAZ gene copy number in severely idiopathic infertile men. Gene deletion of two copies of DAZ (DAZI and 2) was the cause of spermatogenic damage. PMID: 11883873
相關疾病：

Spermatogenic failure Y-linked 2 (SPGFY2)
亞細胞定位：

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.
蛋白家族：

RRM DAZ family
組織特異性：

Testis specific.
數據庫鏈接：

HGNC: 15964

OMIM: 400026

KEGG: hsa:57055

STRING: 9606.ENSP00000371870

UniGene: Hs.592257

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