LTB4R2 Antibody

說明書

中文名稱：

LTB4R2兔多克隆抗體
貨號：

CSB-PA074212
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA074212(LTB4R2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA074212(LTB4R2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q9NPC1
基因名：

LTB4R2
別名：

LTB4R2; BLT2R; BLTR2; Leukotriene B4 receptor 2; LTB4-R 2; LTB4-R2; LTB4 receptor JULF2; Leukotriene B4 receptor BLT2; Seven transmembrane receptor BLTR2
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Synthetic peptide of Human LTB4R2
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:20-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.
基因功能參考文獻：
1. In a group of 545 breast cancer patients with metastasis, authors observed that the high-BLT2 subgroup had a lower disease-free-survival rate than the low-BLT2 subgroup. PMID: 29898809
2. BLT2 gene polymorphism (D196G) enhances ligand sensitivity, thereby increasing cell motility in response to low-dose ligand stimulation. PMID: 29170475
3. Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury. PMID: 27703200
4. BLT2 ligation facilitates F-actin assembly with the upregulated phosphorylation of MYPT1. PMID: 26896822
5. Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor PMID: 28880373
6. RanBPM acts as a negative regulator of BLT2 and IL8, thus attenuating the invasiveness of aggressive breast cancer cells PMID: 28027932
7. BLT2 inhibition induces apoptosis, inhibits proliferation, colony formation and self-renewal capacity of CD34(+) cells from tyrosine kinase inhibitor - resistant blast phase-chronic myeloid leukemia patients. PMID: 26966074
8. Data show that signal transducer and activator of transcription-3 (STAT-3) activation occurs downstream of leukotriene B4 receptor-2 (BLT2) and mediates cisplatin resistance in SK-OV-3 cells. PMID: 26597704
9. Authors demonstrated that MyD88 lies upstream of BLT2 in LPS-potentiated invasiveness and that this 'MyD88-BLT2' cascade mediates activation of NF-kappaB and the synthesis of IL-6 and IL-8 critical for the invasiveness and aggression of breast cancer cells. PMID: 25691060
10. BLT1 and BLT2 are therefore potential targets for the development of novel drugs. PMID: 25480980
11. searched BLT2 downstream components and identified reactive oxygen species and nuclear factor kappaB as critical components that contribute to epithelial-mesenchymal transition in mammary epithelial cells PMID: 24990945
12. BLT2-NOX-ROS-NF-kappaB cascade induction during detachment confers a novel mechanism of anoikis resistance in prostate cancer cells and potentially contributes to prostate cancer progression. PMID: 23986446
13. RanBPM acts as a negative regulator of BLT2 signaling to attenuate BLT2-mediated cell motility PMID: 23928309
14. Findings indicate that BLT2 has a protective role in allergic airway inflammation and that diminished BLT2 expression in CD4(+) T cells may contribute to the pathophysiology of asthma. PMID: 23603839
15. BLT2 is a novel therapeutic target that sensitises drug-resistant breast cancer cells to paclitaxel. PMID: 23799854
16. Findings suggest that, in bronchial epithelial cells, cigarette smoke extracts (CSE) promote induction of pro-inflammatory BLT2 receptors and activate mechanisms leading to increased neutrophil adhesion. PMID: 23347335
17. our study demonstrates that a BLT2 up-regulates IL-8 production , thereby contributing to the invasiveness of these aggressive breast cancer cells. PMID: 23145117
18. LTB4R2 shows splice variation in the 5'-untranslated region and multiple promoter regions. LTB4R2 polymorphisms do not appear to be susceptibility markers for the development of asthma in Caucasian subjects. PMID: 23167751
19. The results suggested that LTB4 receptors BLT1 and BLT2 are involved in IL-8 production in and secretion by human neutrophils induced by T. vaginalis. PMID: 22215047
20. Leukotriene B4 receptor-2 promotes invasiveness and metastasis of ovarian cancer cells through signal transducer and activator of transcription 3 (STAT3)-dependent up-regulation of matrix metalloproteinase 2 PMID: 22396544
21. these findings point to BLT2 as a key regulator of AR expression and will contribute to the development of novel therapies for AR-positive prostate cancers, including androgen-responsive and castration-resistant prostate cancers. PMID: 22426480
22. BLT2 phosphorylation at Thr355 by Akt is necessary for BLT2-mediated chemotaxis PMID: 22044535
23. Up-regulation of BLT2 is associated with bladder cancer. PMID: 21252614
24. BLT2-Nox1-reactive oxygen species-dependent pathway plays a role in promoting the secretion of IL-8 from human mast cells in response to the proinflammatory cytokine IL-1beta, thus contributing to angiogenesis. PMID: 20194723
25. a "BLT2-Nox1"-linked pathway has a crucial role in UVB-induced ROS generation and mediates apoptosis in human keratinocytes PMID: 20090768
26. the 'BLT2-Nox1-ROS'-linked cascade is involved in the pro-survival signaling, especially in ER-negative breast cancer cells. PMID: 19748928
27. BLT2 stimulates the purified G alpha(i2) beta(1) gamma(2) protein more efficiently than the dimer; assembly of two BLT2 protomers into a dimer results in the reduced ability to signal PMID: 20026606
28. BLT2 plays a pivotal, mediatory role in the pathogenesis of asthma, acting through a "reactive oxygen species-NF-kappaB"-linked inflammatory signaling pathway. PMID: 19448154
29. BLT2 is a low-affinity leucotriene B4 receptor; 358 amino acid sequence is 92.7% identical to the mouse receptor PMID: 12895595
30. BLT2 (the low-affinity receptor for LTB4) showed stronger expression than BLT1 (the high-affinity receptor) in actively inflamed synovial tissue from patients with rheumatoid arthritis PMID: 12913925
31. LTB4-BLT2-linked cascade plays a crucial mediatory role in the cell transformation induced by oncogenic Ha-Ras(V12), possibly acting downstream of Rac-cPLA2 PMID: 15489890
32. Data indicate that expression of functional leukotriene B4 receptors (BLT1 and 2) may occur at the surface of endothelial cells in response to lipopolysaccharides, cytokines, and LTB4. PMID: 16624877
33. demonstrates expression of functional Leukotriene B4 receptors, both BLT1 and BLT2, in murine and human mast cells and a regulatory role for stem cell factor in their expression PMID: 16920986
34. BLT2-Nox1-linked cascade is responsible for the elevated ROS generation in Ras-transformed cells. PMID: 18082638
35. Genetic variation in leukotriene pathway members and their receptors confer an increased risk of ischemic stroke in 2 independent populations PMID: 18323512
36. BLT2 was expressed in 45% of ovarian neoplasms and correlated with advanced stage III/IV disease, suboptimal debulking, and platinum resistance. PMID: 18421027
37. Upregulation of BLT2 is already evident in precursor lesions (PanINs, IPMNs). Overexpression of this receptor leads to significant growth stimulation PMID: 18781173
38. LTB4 phosphorylates MAPKs and stimulates NF-kappaB-dependent inflammation via BLT1 and BLT2 receptors in cultured monocytic cells. The blockade of this pathway could be a novel and potential therapeutic target in atherothrombosis. PMID: 18852255
39. the response of the pleural mesothelium to LTB4 is the result of a balance between the activation of receptors for LTB4 with a proinflammatory outcome (BLT2) and the activation of a different receptor for LTB4 with an anti-inflammatory outcome (PPAR). PMID: 18981151
40. results suggest that the helix 8 region of hBLT2 plays an important role in transport-competent receptor folding. PMID: 19126593
41. Findings indicate that BLT2 plays an essential role in mediating VEGF-induced angiogenesis. PMID: 19286633
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
組織特異性：

Widely expressed.
數(shù)據(jù)庫鏈接：

HGNC: 19260

OMIM: 605773

KEGG: hsa:56413

STRING: 9606.ENSP00000433290

UniGene: Hs.642693

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