MTHFD1L Antibody
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中文名稱：MTHFD1L兔多克隆抗體
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貨號：CSB-PA754385ESR2HU
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規格：￥440
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圖片：
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Western blot
All lanes: MTHFD1L antibody at 3.68µg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 106, 30 kDa
Observed band size: 106 kDa -
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA754385ESR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA754385ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) MTHFD1L Polyclonal antibody
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Uniprot No.：
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基因名：MTHFD1L
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別名：10-formyl-THF synthetase antibody; C1TM_HUMAN antibody; Formyltetrahydrofolate synthetase antibody; formyltetrahydrofolate synthetase domain containing 1 antibody; FTHFSDC1 antibody; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like antibody; mitochondrial antibody; Monofunctional C1-tetrahydrofolate synthase antibody; MTC1THFS antibody; MTHFD1L antibody; RP1-292B18.2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Monofunctional C1-tetrahydrofolate synthase, mitochondrial protein (759-978AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2.
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基因功能參考文獻：
- MTHFD1L protein and RNA expression levels were significantly upregulated in esophageal squamous cell carcinoma tissue as compared with normal tissue. High expression of MTHFD1 was also detected in two esophageal cancer cell lines (TE-1 and EC109). PMID: 29171320
- study identifies MTHFD1L in the folate cycle as an important metabolic pathway in cancer cells with the potential for therapeutic targeting PMID: 28394261
- Studies reported that the A allele of a polymorphism in a gene involved in folate metabolism, MTHFD1L, showed a genome-wide significant association with late-onset Alzheimer's Disease. PMID: 26926881
- rs6922269 variant at MTHFD1L gene could be an important prognostic factor for cardiovascular mortality in patients after ACS. PMID: 25809277
- MTHFD1L rs6922269 genotype is associated with active vitamin B12 levels at baseline and may be a marker of prognostic risk in patients with established coronary heart disease. PMID: 24618918
- Results indicate that miR-9 and MiR-197 specifically downregulate MTHFD1L in HEK293 and MCF-7 cells and that SNPrs7646 affects miR-197 binding to the MTHFD1L 3' UTR causing gene repression in the presence of the allele associated with neural tube defects. PMID: 24123340
- The rs3832406 polymorphism was associated with isolated cleft lip with or without cleft palate.(MTHFD1L) PMID: 22520921
- This study support a role of MTHFD1L gene in late-onset Alzheimer's disease in a Northern Han Chinese population. PMID: 22330827
- No evidence of association between the MTHFD1L marker and susceptibility to Alzheimer's disease is found in a sample from a Spanish population. PMID: 21383495
- Prevalence of minor allele A (adenosine) in rs11754661 single nucleotide polymorphism of MTHFD1L contributes to the risk of Alzheimer's disease in a Han population of mainland China. PMID: 21741665
- mitochondrial C1-tetrahydrofolate synthase gene structure and tissue distribution PMID: 12937168
- association of rs6922269 with coronary heart disease not replicated in Tunisian sample PMID: 19373437
- Two of the three alleles of rs3832406 are functionally different and influence the splicing efficiency of the alternate MTHFD1L mRNA transcripts. PMID: 19777576
- Overexpression of C1-tetrahydrofolate synthase in fetal Down syndrome brain at the early second trimester may indicate abnormal folate metabolism and may reflect folate deficiency. PMID: 15068241
- Gene encodes the mitochondrial isozyme of C1-tetrahydrofolate (THF) synthase, a monofunctional enzyme containing formyl-THF synthetase activity. PMID: 16171773
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亞細胞定位：Mitochondrion.
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蛋白家族：Tetrahydrofolate dehydrogenase/cyclohydrolase family; Formate--tetrahydrofolate ligase family
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組織特異性：Detected in most tissues, highest expression found in placenta, thymus and brain. Low expression is found in liver and skeletal muscle. Up-regulated in colon adenocarcinoma.
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數據庫鏈接：
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