SAR1A Antibody
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中文名稱：SAR1A兔多克隆抗體
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貨號：CSB-PA873630ESR2HU
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規格：￥440
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圖片：
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Western blot
All lanes: SAR1A antibody at 4.57μg/ml
Lane 1: Mouse lung tissue
Lane 2: NIH/3T3 whole cell lysate
Lane 3: A431 whole cell lysate
Lane 4: MCF-7 whole cell lysate
Lane 5: Jurkat whole cell lysate
Lane 6: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 23, 18 kDa
Observed band size: 23 kDa -
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA873630ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SAR1A Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：COPII associated small GTPase antibody; COPII-associated small GTPase antibody; GTP binding protein SAR1a antibody; GTP-binding protein SAR1a antibody; Masra 2 antibody; Masra2 antibody; SAR 1 antibody; SAR1 gene homolog A antibody; SAR1 homolog A (S. cerevisiae) antibody; SAR1A antibody; SAR1a gene homolog (S cerevisiae) 1 antibody; SAR1a gene homolog 1 (S cerevisiae) antibody; SAR1a gene homolog 1 antibody; SAR1A_HUMAN antibody; SARA 1 antibody; Sara antibody; SARA1 antibody
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宿主：Rabbit
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反應種屬：Human, Mouse
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免疫原：Recombinant Human GTP-binding protein SAR1a protein (1-198AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).
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基因功能參考文獻：
- Study data suggest that SAR1A and SAR1B are the critical regulators of trafficking of Nav1.5. Moreover, SAR1A and SAR1B interact with MOG1, and are required for MOG1-mediated cell surface expression and function of Nav1.5. PMID: 30251687
- Study shows that the bona fide nonglycoprotein Nox5, a transmembrane superoxide-producing NADPH oxidase, is transported to the cell surface in a manner resistant to co-expression of Sar1 (H79G), a GTP-fixed mutant of the small GTPase Sar1, which blocks COPII vesicle fission from the endoplasmic reticulum. PMID: 29718541
- No associations were observed between any of the secretion associated Ras related GTPase 1A (SAR1a) promoter variants and baseline fetal hemoglobin HbF among sickle cell disease (SCD) patients. PMID: 28499394
- Sar1 is a novel regulator of endoplasmic reticulum-mitochondrial contact sites in the metazoans. PMID: 27101143
- SAR1A gene silencing in hepatocytes mimics the effect of ethanol: dedimerization of giantin, arresting PDIA3 in the endoplasmic reticulum (ER) and large-scale alterations in Golgi architecture. PMID: 26607390
- Data indicate that hydroxyurea (HU) induces SAR1 protein expression, which in turn activates gamma-globin expression, predominantly through the Gialpha/JNK/Jun pathway. PMID: 24914133
- although Sar1A antagonizes the lipoprotein secretion-promoting activity of Sar1B, both isoforms modulate the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol de novo. PMID: 24338480
- Sar1 mutant proteins added to metaphase-arrested Xenopus laevis egg extracts cause dramatic effects on membrane organization. PMID: 22605651
- the behavior of the human of Sar1A and Sar1B, a key component of the COPII family of vesicle coat proteins, was examined. PMID: 22974979
- Sedlin bound and promoted efficient cycling of Sar1, a guanosine triphosphatase that can constrict membranes, and thus allowed nascent carriers to grow and incorporate procollagen prefibrils. PMID: 23019651
- lipid-directed and tether-assisted Sar1 organization controls membrane constriction to regulate ER export. PMID: 20624903
- the intracellular trafficking of hCaR from the endoplasmic reticulum is Sar1-dependent via coat protein complex-II vesicles. PMID: 20457124
- The Sec31 fragment stimulates GAP activity of Sec23/24, and a convergence of Sec31 and Sec23 residues at the Sar1 GTPase active site explains how GTP hydrolysis is triggered leading to COPII coat disassembly. PMID: 17981133
- Sar 1 H79G mutants efficiently blocked the plasma membrane trafficking of the Kir3.1/Kir3.4 complex however they did not block the Gbeta1gamma2/Kir3.1 interaction. PMID: 19135528
- Kir6.2 contains a di-acidic endoplasmic reticulum exit signal, which promotes endoplasmic reticulum exit via a process that requires Sar1. PMID: 19357197
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亞細胞定位：Endoplasmic reticulum. Golgi apparatus.
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蛋白家族：Small GTPase superfamily, SAR1 family
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數據庫鏈接：
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