Recombinant Human Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1), partial

中文名稱：

人EIF4G1重組蛋白
品名簡稱：

Recombinant Human EIF4G1 protein, partial
貨號：

CSB-EP007568HU
說明書：

MSDS Datasheet
規(guī)格：

￥1344
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

EIF4G1
Uniprot No.：

Q04637
別名：

DKFZp686A1451; eIF 4 gamma 1; eIF 4G 1; eIF 4G1; eIF-4-gamma 1; eIF-4G 1; eIF-4G1; EIF4 gamma; EIF4F; EIF4G; EIF4G1; EIF4GI; Eukaryotic translation initiation factor 4 gamma 1; IF4G1_HUMAN; p220
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
來源：

E.coli
分子量：

66.6kDa
表達區(qū)域：

1250-1599aa
氨基酸序列

IEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal GST-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation.
基因功能參考文獻：
1. The polymorphism of the rs200221361 may have no association with the occurrence of Parkinson disease in Uygur and Han people of Xinjiang. PMID: 29718834
2. Epstein-Barr Virus protein EB2 first is recruited to the mRNA cap structure in the nucleus and then interacts with the proteins eIF4G and PABP to enhance the initiation step of translation. PMID: 29142127
3. EIF4G1 overexpression is associated with non-small cell lung cancers. PMID: 27003362
4. High EIF4G expression is associated with malignant peripheral nerve sheath tumors and vestibular schwannomas. PMID: 26951381
5. The study indicates that the EIF4G1 mutation is rare in Taiwan, which is consistent with other reports from Asia. Ethnicity could have a great influence on EIF4G1 in Parkinson's disease. PMID: 26490695
6. the IRES of encephalomyocarditis virus (EMCV) interacts with the HEAT-1 domain of eukaryotic initiation factor 4G (eIF4G). PMID: 27525590
7. EIF4G1 mutations are not related to Parkinson's disease PMID: 26022768
8. VPS35 D620N and EIF4G1 R1205H mutations are not a common cause of Parkinson disease in the Greek population. PMID: 26300542
9. EIF4GI shares this activity and also interacts with eIF1. PMID: 25738462
10. EIF4G1 is neither a strong nor a common risk factor for Parkinson's disease: evidence from large European cohorts. PMID: 25368108
11. This study therefore implicates c-Myc as a potential regulator of the cancer-promoting effects of equol via up-regulation of eIF4GI and selective initiation of translation on mRNAs that utilize non-canonical initiation, including certain oncogenes PMID: 25593313
12. Knockdown of eIF4GI was deleterious to myeloma cells phenotype and expression of specific molecular targets (SMAD5/ERalpha/HIF1alpha/c-Myc). PMID: 24815186
13. Its mutation is not a common cause of familial Parkinson's disease. PMID: 24854799
14. in a generic cell model, new insights into the mechanisms whereby the FSH receptor controls translation have been gained. Rapamycin-sensitive eIF4G phosphorylation at the 5' cap may be a surrogate for the classical exchange between eIF4G and 4E-BP1. PMID: 24711644
15. The results of this study did not identify novel or previously reported pathogenic mutations (including the p.A502V and p.R1205H mutants) within EIF4G1 in the Japanese population. PMID: 24704100
16. Data suggest that, in eIF4G/eif4A complex, eIF4G1 exhibits low-affinity ATP binding site in proximity of ATP-binding cleft of eif4A enhancing ATP binding; additional enhancement of eIF4G/eif4A binding is observed in crowded/intracellular environment. PMID: 25255371
17. study revealed that the EIF4G1 R1205H and VPS35 D620N mutations were absent in 418 Parkinsoin Disease patients of various South African ethnic groups PMID: 24080171
18. Report EIF4G binding within the IRES domain V of the coxsackie virus B3 mutant strain. PMID: 24063684
19. Its mutation causes Parkinson's disease in Indian population. PMID: 23726718
20. eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome. PMID: 24092755
21. EIF4G1 mutations do not appear to play a role in patients with Parkinson disease from southwest China. PMID: 23261770
22. The eIF4E-binding site in eukaryotic initiation factor 4G (eIF4G) functions as an autoinhibitory domain to modulate its ability to stimulate eIF4A helicase activity. PMID: 23901100
23. The data of this study indicated that in an ethnic Chinese population, the pathogenic mutation p.R1205H in EIF4G1 is not common and that EIF4G1 exonic variants rs2178403 and rs13319149 are not associated with parkinson disease. PMID: 23617574
24. The results suggest that in some patients variants in EIF4G1 can be associated with pathology that has a high likelihood of association with clinical features of dementia with Lewy bodies. PMID: 23124435
25. the EIF4G1 p.Ala502Val and p.Arg1205His variants are a rare cause of PD, at least in Chinese population. PMID: 23562511
26. In agreement with recent reports we conclude that convincing evidence establishes EIF4G1 mutations as a rare cause of Parkinson's disease PMID: 23490116
27. eIF4GI participates in the miRNA-mediated post-transcriptional gene silencing by promoting the association of Ago2 with the cap-binding complex. PMID: 23409027
28. EIF4G1 is an uncommon cause of PD in our Asian cohort. PMID: 23092605
29. There is no evidence for an overall contribution of genetic variability in EIF4G1 (or VPS35) to Parkinson disease development in this large family. PMID: 23408866
30. Results provide a mechanistic link between intracellular signal transduction and dynamic initiation complex formation coordinated by flexible eIF4G structure. PMID: 23263986
31. Data show that eIF4G interacts with the RRM2 domain of polyadenylate-binding protein-1 (PABP). PMID: 23041282
32. Increased expression of eIF4G1 therefore promotes specialized translation of survival, growth arrest, and DDR mRNAs that are important in cell survival and DNA repair following genotoxic DNA damage. PMID: 23112151
33. EIF4G1 cDNAs, encoding different isoforms which arise through selection of alternative initiation codons, rescued translation from siRNA interference to different extents PMID: 22909319
34. analysis of variants of eukaryotic translation initiation factor 4G1 in sporadic Parkinson\'s disease PMID: 22707335
35. These data do not support the pathogenicity of several EIF4G1 variants in PD, at least in the French population. PMID: 22658323
36. linkage analysis, mutations in EIF4G1 were implicated as a cause of Parkinson disease and mutations in SLC20A2 as a cause of familial idiopathic basal ganglia calcification. PMID: 22772876
37. Found that either EIF4G1 variants are an extremely rare cause of familial Parkinson's Disease in Caucasian cohorts, or that A502V is in fact a rare benign variant not involved in Parkinson's Disease aetiology PMID: 22561553
38. This finding demonstrates that viruses can increase host translation initiation factor concentration to foster their replication and defines a unique mechanism whereby control of PABP abundance regulates eIF4F assembly. PMID: 22431630
39. The ssDNA-binding protein of Vaccinia virus, I3 interacts and co-localizes with the eIF4F scaffold protein, eIF4G inInfected cells. PMID: 22280895
40. EIF4G1 mutations implicate mRNA translation initiation in familial parkinsonism. PMID: 21907011
41. Data show that PKCalpha activation elicits a cascade of orchestrated phosphorylation events that may modulate eIF4G1 structure and control interaction with the eIF4E kinase, Mnk1. PMID: 21576361
42. EIF4G1 can serve as a biomarker for the prognosis of nasopharyngeal carcinoma patients. PMID: 20398343
43. HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage PMID: 19956697
44. findings assign NAD(P)H quinone-oxydoreductase 1 an original role in the regulation of mRNA translation via the control of eIF4GI stability by the proteasome. PMID: 20028737
45. mass spectrometric analysis of N terminus reveals novel isoforms PMID: 11821405
46. demonstrate that the expression of the amino-terminal one-third of eIF4G, which interacts with eIF4E and PABP, in Xenopus oocyte inhibits translation and progesterone-induced maturation PMID: 11866104
47. data suggest that expression of the eIF4GI isoforms is partly controlled by a complex translation strategy involving both cap-dependent and cap-independent mechanisms PMID: 12052860
48. X-ray structure of rotavirus NSP3-C bound to the 30 residue fragment of eIF4G that is also recognized by poly(A) binding protein (PABP) PMID: 12086624
49. proteolytic activity of HIV-1 protease on eIF4GI and eIF4GII and its implications for the translation of mRNAs PMID: 12505164
50. Overexpression of EIF4G1 causes aberrant cell morphology and results in disruption of the localization of F-actin and the organization of microtubules. PMID: 12581158
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相關疾病：

Parkinson disease 18 (PARK18)
亞細胞定位：

Cytoplasm, Stress granule.
蛋白家族：

Eukaryotic initiation factor 4G family
數(shù)據(jù)庫鏈接：

HGNC: 3296

OMIM: 600495

KEGG: hsa:1981

STRING: 9606.ENSP00000338020

UniGene: Hs.433750