Recombinant Human Protoheme IX farnesyltransferase, mitochondrial (COX10), partial

中文名稱：

Recombinant Human Protoheme IX farnesyltransferase, mitochondrial(COX10),partial
貨號：

CSB-YP621520HU
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Protoheme IX farnesyltransferase, mitochondrial(COX10),partial
貨號：

CSB-EP621520HU
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Protoheme IX farnesyltransferase, mitochondrial(COX10),partial
貨號：

CSB-EP621520HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Protoheme IX farnesyltransferase, mitochondrial(COX10),partial
貨號：

CSB-BP621520HU
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Protoheme IX farnesyltransferase, mitochondrial(COX10),partial
貨號：

CSB-MP621520HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

COX10
Uniprot No.：

Q12887
別名：

2410004F01Rik; AU042636; COX10; COX10_HUMAN; Cytochrome c oxidase assembly protein; Cytochrome c oxidase subunit X; Heme A farnesyltransferase; Heme O synthase; OTTMUSP00000006085; Protoheme IX farnesyltransferase; mitochondrial; Protoheme IX farnesyltransferase; mitochondrial precursor; RP23-78H18.1
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Converts protoheme IX and farnesyl diphosphate to heme O.
基因功能參考文獻：
1. On the basis of its pivotal role in regulating cell death upon COX dysfunction, CerS6 might potentially represent a novel target for therapeutic intervention in mitochondrial diseases caused by COX dysfunction. PMID: 25766330
2. ISCU and COX10 are target genes of miR-210 related to mitochondrial metabolism PMID: 20498629
3. COX 15 mRNA was significantly more abundant in the cerebral tissue of Alzheimer's disease (AD) patients and COX10 and COX15 SNP were significantly less represented in the patient group, suggesting a possible protective role toward the risk for AD PMID: 19826901
4. The expression of the AOX, well-tolerated by the cells, compensates for both the growth defect and the pronounced oxidant-sensitivity of COX-deficient human cells. PMID: 20049701
5. Cytochrome c oxidase is decreased significantly in platelets and hippocampus in Alzheimer patients compared to controls. PMID: 11959398
6. COX10 has a role in mitochondrial heme A biosynthesis PMID: 12928484
7. This study report a cytochrome c oxidase (COX)-deficient patient, clinically affected with Leigh-like disease, with a homozygous mutation in the COX10 start codon. PMID: 15455402
8. Geranylgeranyltransferase inhibitor-2147 (GGTI-2147), an inhibitor of this enzyme prenylation, elicited significant inhibition of glucose-stimulated insulin secretion from INS 832/13 islet cells. PMID: 17192483
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相關疾病：

Mitochondrial complex IV deficiency (MT-C4D); Leigh syndrome (LS)
亞細胞定位：

Mitochondrion membrane; Multi-pass membrane protein.
蛋白家族：

UbiA prenyltransferase family
數據庫鏈接：

HGNC: 2260

OMIM: 220110

KEGG: hsa:1352

STRING: 9606.ENSP00000261643

UniGene: Hs.462278