Recombinant Mouse Neuropeptide Y receptor type 4 (Ppyr1)

in vitro E.coli expression system

中文名稱(chēng)：

小鼠Npy4r重組蛋白
貨號(hào)：

CSB-CF720235MO
說(shuō)明書(shū)：

Datasheet
規(guī)格：
來(lái)源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

基因名：

Npy4r
Uniprot No.：

Q61041
別名：

Npy4r; Ppyr1; Neuropeptide Y receptor type 4; NPY4-R; NPYR-D; Pancreatic polypeptide receptor 1; PP1
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

1-375
氨基酸序列

MNTSHFLAPLFPGSLQGKNGTNPLDSPYNFSDGCQDSAELLAFIITTYSIETILGVLGNL CLIFVTTRQKEKSNVTNLLIANLAFSDFLMCLICQPLTVTYTIMDYWIFGEVLCKMLTFI QCMSVTVSILSLVLVALERHQLIINPTGWKPSIFQAYLGIVVIWFVSCFLSLPFLANSTL NDLFHYNHSKVVEFLEDKVVCFVSWSSDHHRLIYTTFLLLFQYCIPLAFILVCYIRIYQR LQRQKHVFHAHACSSRAGQMKRINSMLMTMVTAFAVLWLPLHVFNTLEDWYQEAIPACHG NLIFLMCHLLAMASTCVNPFIYGFLNINFKKDIKALVLTCHCRSPRGESEHLPLSTVHTD LSKGSMRMGSKSNFI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP >> PYY >= NPY.
基因功能參考文獻(xiàn)：
1. Genetic deletion of the Y4 receptor impaired fear extinction, an effect that was rescued by short-term fasting PMID: 26062787
2. Data from studies in knockout mice suggest that signaling through Y4 receptor prevents development of short-/long-term anxiety-/depression-like behaviour caused by acute immune challenge. Study includes comparison with Y2 receptor knockout mice. PMID: 19939871
3. These findings show that pancreatic polypeptide reduces food intake predominantly via stimulation of the anorexigenic alpha-MSH signaling pathway, and that this effect is mediated by direct action on local Y4 receptors within the arcuate nucleus. PMID: 20041129
4. fasting inhibits the somatotropic axis via direct action on Y2 receptors in the Arcuate nucleus and indirectly inhibits the gonadotropic axis via Y4 receptors PMID: 17272395
5. Y4 receptors play an important role in the regulation of behavioral homeostasis PMID: 18221379
6. The neuropeptide Y (NPY)-Y4 receptor knockout mice Increased novelty-induced motor activity and reduced depression-like behavior. PMID: 19121371
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亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
組織特異性：

Heart, detected in small intestine.
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:19065

STRING: 10090.ENSMUSP00000056576

UniGene: Mm.57059