AMHR2
抗繆勒氏管激素II型受體（AMHR2）又稱繆勒抑制物質(zhì)受體II型，在性別分化過程中具有關(guān)鍵調(diào)控作用。該受體主要分布于性腺組織，通過與抗繆勒氏管激素（AMH）特異性結(jié)合，激活SMAD信號(hào)級(jí)聯(lián)反應(yīng)，進(jìn)而抑制女性生殖管道的發(fā)育。臨床研究發(fā)現(xiàn)，AMHR2基因突變可導(dǎo)致持續(xù)性繆勒管綜合征，出現(xiàn)子宮、輸卵管殘留等生殖系統(tǒng)異常。近年來該受體在婦科腫瘤領(lǐng)域備受關(guān)注，約80%的卵巢顆粒細(xì)胞瘤存在AMHR2過表達(dá)現(xiàn)象，其激活狀態(tài)與腫瘤增殖、轉(zhuǎn)移密切相關(guān)。針對(duì)AMHR2的治療策略已進(jìn)入轉(zhuǎn)化階段，單克隆抗體藥物STRO-002已完成治療卵巢癌的I期臨床試驗(yàn)，小分子抑制劑KY-273也在臨床前研究中顯示出抑制腫瘤生長(zhǎng)的潛力。
熱銷產(chǎn)品
AMHR2 Antibody (CSB-PA614985ESR1HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human adrenal glands tissue using CSB-PA614985ESR1HU at dilution of 1:50
Immunofluorescence staining of HepG2 cells with CSB-PA614985ESR1HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Human Anti-Muellerian hormone type-2 receptor(AMHR2) ELISA kit (CSB-EL001667HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL001667HU
規(guī)格：96T/48T
靈敏度：8 pg/mL
檢測(cè)范圍：0.32 ng/mL-12 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
AMHR2 Antibodies
AMHR2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA614985ESR1HU | AMHR2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA311389 | AMHR2 Antibody | Human,Mouse,Rat | ELISA,IHC |
AMHR2 Proteins
AMHR2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP614985HU CSB-EP614985HU CSB-BP614985HU CSB-MP614985HU CSB-EP614985HU-B |
Recombinant Human Anti-Muellerian hormone type-2 receptor (AMHR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AMHR2 ELISA Kit
AMHR2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL001667HU | Human Anti-Muellerian hormone type-2 receptor(AMHR2) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 8 pg/mL |
