BTLA

BTLA，即B和T淋巴細(xì)胞弱化因子，別名BTNL9、BTLA。它是一種主要在T細(xì)胞、B細(xì)胞和NK細(xì)胞上表達(dá)的免疫檢查點(diǎn)分子，由人體細(xì)胞自身的基因編碼。BTLA的作用機(jī)制涉及與其特異性配體HVEM（皰疹病毒入侵介質(zhì)）結(jié)合，這種結(jié)合能夠抑制T細(xì)胞和B細(xì)胞的活化、增殖以及細(xì)胞因子的生成。BTLA與HVEM的結(jié)合通過(guò)激活免疫受體酪氨酸的抑制基序（ITIM）和免疫球蛋白酪氨酸開(kāi)關(guān)基序（ITSM），導(dǎo)致SHP-1和SHP-2的磷酸化和募集，從而抑制T細(xì)胞的增殖和IL-2的產(chǎn)生，產(chǎn)生免疫抑制效應(yīng) 。BTLA參與了多種生理和病理過(guò)程的調(diào)節(jié)，包括腫瘤、炎癥性疾病、自身免疫性疾病等。在腫瘤微環(huán)境中，BTLA的激活是PD-1抗體的潛在耐藥機(jī)制之一，BTLA的表達(dá)與腫瘤的進(jìn)展密切相關(guān)。在炎癥性疾病中，BTLA對(duì)T細(xì)胞介導(dǎo)的炎癥具有負(fù)調(diào)節(jié)作用。此外，在自身免疫性疾病中，BTLA的表達(dá)水平與疾病的活動(dòng)性相關(guān)。因此，BTLA是免疫學(xué)研究和相關(guān)疾病治療中的一個(gè)潛在靶點(diǎn) 。

熱銷(xiāo)產(chǎn)品

Recombinant Human B- and T-lymphocyte attenuator (BTLA), partial (Active) (CSB-MP773799HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized BTLA at 5 μg/ml can bind biotinylated human TNFRSF14 (CSB-MP842173HU-A), the EC₅₀ is 137.8-233.4 ng/ml.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human BTLA at 2μg/ml can bind Anti-BTLA recombinant antibody(CSB-RA773799MAIHU), the EC₅₀ is 1.763-3.542 ng/mL.

BTLA Recombinant Monoclonal Antibody (CSB-RA773799MA1HU)

驗(yàn)證數(shù)據(jù)

The Binding Activity of Human BTLA with Anti-BTLA Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human BTLA(CSB-MP773799HU1)at 2 μg/mL can bind Anti-BTLA recombinant antibody , the EC₅₀ is 11.56-13.00 ng/mL.

Untransfected Jurkat cells surface (green line) and transfected Human BTLA Jurkat stable cells surface (red line) were stained with anti-BTLA antibody (2μg/1*10⁶cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

Untransfected CHO-K1*10⁶cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

BTLA Antibody

BTLA Protein

BTLA ELISA Kit

BTLA Antibodies

BTLA for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	種屬反應(yīng)性	應(yīng)用類(lèi)型
CSB-PA921165	BTLA Antibody	Human	ELISA,WB
CSB-PA007471	BTLA Antibody	Human	WB, ELISA
CSB-PA100659	BTLA Antibody	Human	ELISA,IHC
CSB-PA921825	BTLA Antibody	Human	ELISA,IHC
CSB-PA446647	BTLA Antibody	Human	IHC,ELISA
CSB-RA773799MA1HU	BTLA Recombinant Monoclonal Antibody	Human	ELISA, FC

BTLA Proteins

BTLA Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP742519MO CSB-EP742519MO CSB-BP742519MO CSB-MP742519MO CSB-EP742519MO-B	Recombinant Mouse B- and T-lymphocyte attenuator (Btla), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BTLA Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP744141RA CSB-EP744141RA CSB-BP744141RA CSB-MP744141RA CSB-EP744141RA-B	Recombinant Rat B- and T-lymphocyte attenuator (Btla), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BTLA Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP773799HU CSB-EP773799HU CSB-BP773799HU CSB-EP773799HU-B	Recombinant Human B- and T-lymphocyte attenuator (BTLA), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP773799HU	Recombinant Human B- and T-lymphocyte attenuator (BTLA), partial (Active)	Mammalian cell
CSB-MP773799HU-B	Recombinant Human B- and T-lymphocyte attenuator (BTLA), partial,Biotinylated	Mammalian cell
CSB-MP773799HU1	Recombinant Human B- and T-lymphocyte attenuator(BTLA), partial (Active)	Mammalian cell