IDH2
IDH2（異檸檬酸脫氫酶2）是一種線粒體酶，由α、β和γ三個亞基組成，形成α2βγ異源四聚體，并進一步組裝成八聚體結構。IDH2的主要功能是催化異檸檬酸氧化脫羧生成α-酮戊二酸（α-KG），同時將NADP+轉化為NADPH，參與三羧酸循環（TCA cycle），對細胞代謝和能量產生至關重要。NADPH作為一種抗氧化劑，有助于維持細胞氧化還原狀態的穩定，并促進脂肪酸等大分子的合成。IDH2參與的信號通路包括三羧酸循環、氧化還原穩態的維持，以及與腫瘤發生發展相關的代謝途徑。IDH2的突變在急性髓系白血?。ˋML）等腫瘤中較為常見，與腫瘤細胞的異常代謝和分化障礙有關。因此，IDH2不僅在細胞代謝中發揮關鍵作用，其突變還與腫瘤的發生發展密切相關，使其成為研究腫瘤代謝和開發新療法的重要靶點。
熱銷產品
IDH2 Antibody (CSB-PA010990ESR1HU)
驗證數據
Western blot
All lanes: IDH2 antibody at 5µg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 51, 46 kDa
Observed band size: 51 kDa
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA010990ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA010990ESR1HU at dilution of 1:100
IDH2 Antibodies
IDH2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA010990GA01HU | IDH2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA010990ESR2HU | IDH2 Antibody | Human, Mouse | ELISA, WB |
| CSB-PA010990ESR1HU | IDH2 Antibody | Human | ELISA, WB, IHC |
| CSB-PA148538 | IDH2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA586287 | IDH2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
IDH2 Proteins
IDH2 Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010990PI CSB-EP010990PI CSB-BP010990PI CSB-MP010990PI CSB-EP010990PI-B |
Recombinant Pig Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010990HU CSB-EP010990HU CSB-BP010990HU CSB-MP010990HU CSB-EP010990HU-B |
Recombinant Human Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010990MO CSB-EP010990MO CSB-BP010990MO CSB-MP010990MO CSB-EP010990MO-B |
Recombinant Mouse Isocitrate dehydrogenase [NADP], mitochondrial (Idh2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010990RA CSB-EP010990RA CSB-BP010990RA CSB-MP010990RA CSB-EP010990RA-B |
Recombinant Rat Isocitrate dehydrogenase [NADP], mitochondrial (Idh2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP310511DOA CSB-EP310511DOA CSB-BP310511DOA CSB-MP310511DOA CSB-EP310511DOA-B |
Recombinant Arabidopsis thaliana Isocitrate dehydrogenase [NAD] regulatory subunit 2, mitochondrial (IDH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP340961SVG CSB-EP340961SVG CSB-BP340961SVG CSB-MP340961SVG CSB-EP340961SVG-B |
Recombinant Saccharomyces cerevisiae Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial (IDH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP528404KBK CSB-EP528404KBK CSB-BP528404KBK CSB-MP528404KBK CSB-EP528404KBK-B |
Recombinant Kluyveromyces lactis Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial (IDH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP680991MOV CSB-EP680991MOV CSB-BP680991MOV CSB-MP680991MOV CSB-EP680991MOV-B |
Recombinant Macaca fascicularis Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP891493SXV CSB-EP891493SXV CSB-BP891493SXV CSB-MP891493SXV CSB-EP891493SXV-B |
Recombinant Schizosaccharomyces pombe Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial (idh2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
