LIFR
LIFR，即白血病抑制因子受體，別名LIF-R、CD118等。它來源于人類基因組，編碼一種屬于I型細(xì)胞因子受體家族的蛋白質(zhì)。LIFR通過與高親和力的轉(zhuǎn)換亞單位gp130結(jié)合形成受體復(fù)合物，介導(dǎo)白血病抑制因子的作用，后者是一種多功能細(xì)胞因子，參與成人和胚胎的細(xì)胞分化、增殖和存活。在生物學(xué)上，LIFR的突變與Schwartz-Jampel綜合征2型等疾病相關(guān)，揭示了其在維持細(xì)胞正常功能和預(yù)防疾病中的重要作用。此外，LIFR還參與多種細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)過程，對細(xì)胞生長、分化和凋亡等生理活動(dòng)具有廣泛影響。
熱銷產(chǎn)品
Recombinant Human Leukemia inhibitory factor receptor (LIFR), partial (Active) (CSB-MP012929HUi9)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized human LIF (CSB-MP012928HU) at 2 μg/ml can bind human LIFR, the EC50 is 11.68-15.52 ng/ml.
LIFR Antibody (CSB-PA012929LA01HU)
驗(yàn)證數(shù)據(jù)
Immunofluorescence staining of A549 cells with CSB-PA012929LA01HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Western Blot
Positive WB detected in: MCF7 whole cell lysate,Rat Brain tissue lysate
All lanes: LIFR antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 123 kDa
Observed band size: 123 kDa
LIFR Antibodies
LIFR for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006260 | LIFR Antibody | Human | WB, ELISA |
| CSB-PA620805 | LIFR Antibody | Human | ELISA,IHC |
| CSB-PA939111 | LIFR Antibody | Human | ELISA,IHC |
| CSB-PA012929LA01HU | LIFR Antibody | Human, Rat | ELISA, WB, IF |
| CSB-PA012929LB01HU | LIFR Antibody, HRP conjugated | Human | ELISA |
| CSB-PA012929LC01HU | LIFR Antibody, FITC conjugated | Human | |
| CSB-PA012929LD01HU | LIFR Antibody, Biotin conjugated | Human | ELISA |
LIFR Proteins
LIFR Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012929HU CSB-EP012929HU CSB-BP012929HU CSB-EP012929HU-B |
Recombinant Human Leukemia inhibitory factor receptor (LIFR), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP012929HUi9 | Recombinant Human Leukemia inhibitory factor receptor (LIFR), partial (Active) | Mammalian cell |
| CSB-MP012929HU | Recombinant Human Leukemia inhibitory factor receptor (LIFR), partial | Mammalian cell |
LIFR Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012929MO CSB-EP012929MO CSB-BP012929MO CSB-MP012929MO CSB-EP012929MO-B |
Recombinant Mouse Leukemia inhibitory factor receptor (Lifr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LIFR Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012929RA CSB-EP012929RA CSB-BP012929RA CSB-MP012929RA CSB-EP012929RA-B |
Recombinant Rat Leukemia inhibitory factor receptor (Lifr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LIFR Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP719896DO CSB-EP719896DO CSB-BP719896DO CSB-MP719896DO CSB-EP719896DO-B |
Recombinant Dog Leukemia inhibitory factor receptor (LIFR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
