MAP2K2
MAP2K2，即絲裂原活化蛋白激酶激酶2，別名MEK2、MKK2等。它是一種雙特異性蛋白激酶，屬于MAP激酶激酶家族成員，由人體細(xì)胞自身的基因編碼。MAP2K2在細(xì)胞的增殖、分化、細(xì)胞粘附和轉(zhuǎn)錄等多種生物學(xué)過(guò)程中發(fā)揮著重要作用。其作用機(jī)制主要是通過(guò)接受上游RAF激酶的磷酸化激活信號(hào)，進(jìn)而對(duì)下游的ERK1/2（胞外信號(hào)調(diào)節(jié)激酶1/2）進(jìn)行磷酸化，從而激活ERK1/2作為轉(zhuǎn)錄調(diào)節(jié)因子 。MAP2K2在生物學(xué)上的意義非常重大，它參與調(diào)控的信號(hào)通路是細(xì)胞增殖、應(yīng)激、炎癥、分化、功能同步化、轉(zhuǎn)化、凋亡等信號(hào)轉(zhuǎn)導(dǎo)通路的共同交匯通路之一。MAP2K2的活性對(duì)于細(xì)胞對(duì)多種生長(zhǎng)因子、細(xì)胞因子、射線(xiàn)、滲透壓等刺激的響應(yīng)至關(guān)重要。此外，MAP2K2的異常激活與多種癌癥的發(fā)生發(fā)展有關(guān)，其抑制或降解也參與了某些病原體如耶爾森菌和炭疽的致病機(jī)制 。
熱銷(xiāo)產(chǎn)品
MAP2K2 Antibody (CSB-PA04909A0Rb)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: HL60 whole cell lysate
All lanes: MAP2K2 antibody at 2.8µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 45 kDa
Observed band size: 45 kDa
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA04909A0Rb at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA04909A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
MAP2K2 Antibodies
MAP2K2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA013411GA01HU | MAP2K2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA062510 | Phospho-MAP2K2 (Thr394) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA898246 | MAP2K2 (Ab-394) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA000570 | Phospho-MAP2K2 (T394) Antibody | Human,Mouse,Rat | WB, IHC, IP, ELISA |
| CSB-PA030302 | MAP2K2 Antibody | Human,Mouse,Rat | WB, IHC, IP, ELISA |
| CSB-PA080229 | MAP2K2 Antibody | Human,Mouse,Rat | WB, IHC |
| CSB-PA097880 | MAP2K2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA224661 | MAP2K2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA04909A0Rb | MAP2K2 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA04909C0Rb | MAP2K2 Antibody, FITC conjugated | Human | |
| CSB-PA04909D0Rb | MAP2K2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA101222 | MAP2K2 Antibody | Human | WB, IHC, ELISA |
| CSB-MA671424 | MAP2K2 Monoclonal Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF,IP |
MAP2K2 Proteins
MAP2K2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP013411HU CSB-EP013411HU CSB-BP013411HU CSB-MP013411HU CSB-EP013411HU-B |
Recombinant Human Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MAP2K2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP013411RA CSB-EP013411RA CSB-BP013411RA CSB-MP013411RA CSB-EP013411RA-B |
Recombinant Rat Dual specificity mitogen-activated protein kinase kinase 2 (Map2k2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MAP2K2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP626627DO CSB-EP626627DO CSB-BP626627DO CSB-MP626627DO CSB-EP626627DO-B |
Recombinant Dog Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MAP2K2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP723614MO CSB-EP723614MO CSB-BP723614MO CSB-MP723614MO CSB-EP723614MO-B |
Recombinant Mouse Dual specificity mitogen-activated protein kinase kinase 2 (Map2k2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MAP2K2 Proteins for Cyprinus carpio (Common carp)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP835446EQE CSB-EP835446EQE CSB-BP835446EQE CSB-MP835446EQE CSB-EP835446EQE-B |
Recombinant Cyprinus carpio Dual specificity mitogen-activated protein kinase kinase 2 (map2k2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MAP2K2 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP838569CH CSB-EP838569CH CSB-BP838569CH CSB-MP838569CH CSB-EP838569CH-B |
Recombinant Chicken Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
