SYK
SYK，即脾酪氨酸激酶，別名KSYK、p72syk。SYK由人類SYK基因編碼，該基因廣泛表達(dá)于造血細(xì)胞中，并涉及將激活的免疫受體耦合到介導(dǎo)多種細(xì)胞反應(yīng)的下游信號(hào)事件，包括增殖、分化和吞噬作用。SYK的作用機(jī)制涉及其作為非受體型Tyr蛋白激酶家族成員，在B細(xì)胞受體（BCR）反應(yīng)中扮演中心角色，作為上游激活器激活PI3K、PLCgamma2和Rac/cdc42等途徑。SYK在適應(yīng)性免疫受體信號(hào)傳導(dǎo)中發(fā)揮著至關(guān)重要的作用，并且近期研究顯示SYK還介導(dǎo)其他多樣化的生物學(xué)功能，包括細(xì)胞粘附、先天免疫識(shí)別、破骨細(xì)胞成熟、血小板活化和血管發(fā)育等。SYK在自身免疫性疾病和血液惡性腫瘤中也發(fā)揮著至關(guān)重要的作用。
熱銷產(chǎn)品
SYK Antibody (CSB-PA022998LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA022998LA01HU at dilution of 1:100
Immunofluorescence staining of HepG2 cells with CSB-PA022998LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
SYK Antibodies
SYK for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA055006 | Phospho-SYK (Tyr323) Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA572454 | SYK (Ab-323) Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA556441 | Phospho-SYK (Tyr352) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA938706 | SYK Antibody | Human | ELISA,WB |
| CSB-PA000697 | Phospho-SYK (Y348) Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA000698 | Phospho-SYK (Y525) Antibody | Human, Mouse, Rat, Monkey | WB, IHC, ELISA |
| CSB-PA004198 | SYK Antibody | Human | WB, IHC, ELISA |
| CSB-PA004199 | SYK Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA050187 | Phospho-SYK (Y352) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA050188 | Phospho-SYK (Y323) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA050189 | SYK Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA050190 | SYK Antibody | Human,Mouse,Rat | IHC, IF, ELISA |
| CSB-PA050191 | SYK Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA832352 | SYK Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA436831 | SYK Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA022998LA01HU | SYK Antibody | Human | ELISA, IHC, IF |
| CSB-PA022998LD01HU | SYK Antibody, Biotin conjugated | Human | ELISA |
SYK Proteins
SYK Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022998HU CSB-EP022998HU CSB-BP022998HU CSB-MP022998HU CSB-EP022998HU-B |
Recombinant Human Tyrosine-protein kinase SYK (SYK) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SYK Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022998MO CSB-EP022998MO CSB-BP022998MO CSB-MP022998MO CSB-EP022998MO-B |
Recombinant Mouse Tyrosine-protein kinase SYK (Syk) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SYK Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022998CH CSB-EP022998CH CSB-BP022998CH CSB-MP022998CH CSB-EP022998CH-B |
Recombinant Chicken Tyrosine-protein kinase SYK (SYK), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SYK Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP714515RA CSB-EP714515RA CSB-BP714515RA CSB-MP714515RA CSB-EP714515RA-B |
Recombinant Rat Tyrosine-protein kinase SYK (Syk) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
