VEGFA
VEGFA，全稱血管內(nèi)皮生長因子A，是一種重要的蛋白質(zhì)，在血管生成和腫瘤生長中發(fā)揮關(guān)鍵作用。它也被稱為血管通透性因子（VPF），能夠促進(jìn)內(nèi)皮細(xì)胞增殖、遷移，并抑制細(xì)胞凋亡，從而增強血管通透性。VEGFA通過與受體VEGFR1和VEGFR2結(jié)合，激活下游信號通路，促進(jìn)血管內(nèi)皮細(xì)胞增殖和遷移，進(jìn)而誘導(dǎo)血管生成。此外，VEGFA還能影響免疫細(xì)胞功能，如抑制樹突細(xì)胞成熟和破壞造血前體細(xì)胞分化，并誘導(dǎo)免疫抑制相關(guān)分子PD-L1的表達(dá)，從而影響腫瘤微環(huán)境。
VEGFA與多種疾病密切相關(guān)，尤其是腫瘤，如結(jié)直腸癌、非小細(xì)胞肺癌、腦膠質(zhì)瘤等。由于其在腫瘤血管生成中的重要作用，VEGFA已成為重要的藥物靶點。目前，全球首個上市的VEGFA單克隆抗體腫瘤藥物為羅氏開發(fā)的貝伐珠單抗（Avastin），已獲批用于多種腫瘤的治療。此外，還有多種VEGFA抑制劑正在研發(fā)中，如基石藥業(yè)的CS2009，這是一款靶向PD-1、VEGFA和CTLA-4的新型三特異性抗體，展現(xiàn)出良好的抗腫瘤活性。VEGFA相關(guān)藥物的研發(fā)為腫瘤治療提供了新的選擇。
熱銷產(chǎn)品
驗證數(shù)據(jù)
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
-AC1.jpg)
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human VEGFA protein at 2 μg/ml can bind Anti-VEGFA recombinant antibody (CSB-RA025833MA2HU). The EC50 is 0.6797-0.8382 ng/mL.
-AC2.jpg)
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human FLT1 (CSB-MP008732HU) protein at 2 μg/ml can bind Human VEGFA protein. The EC50 is 28.72-33.22 ng/mL.
Recombinant Human Vascular endothelial growth factor A (VEGFA) (CSB-EP025833HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
VEGFA Recombinant Monoclonal Antibody (CSB-RA025833MA1HU)
驗證數(shù)據(jù)
IHC image of CSB-RA025833MA1HU diluted at 1:50 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
Immunofluorescence staining of hela cell with CSB-RA025833MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunofluorescence staining of MCF7 cell with CSB-RA025833MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).
VEGFA Antibodies
VEGFA for Pig
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA025833LA01PI | VEGFA Antibody | Pig | ELISA |
| CSB-PA025833LD01PI | VEGFA Antibody, Biotin conjugated | Pig | ELISA |
VEGFA for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA025833GA01HU | VEGFA Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA004762 | VEGFA Antibody | Human | WB, ELISA |
| CSB-PA060064 | VEGFA Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA379558 | VEGFA Antibody | Human | ELISA,WB,IHC |
| CSB-PA793155 | VEGFA Antibody | Human | ELISA,WB |
| CSB-PA07529A0Rb | VEGFA Antibody | Human | ELISA |
| CSB-PA07529D0Rb | VEGFA Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA07529C0Rb | VEGFA Antibody, FITC conjugated | Human | |
| CSB-PA07529B0Rb | VEGFA Antibody, HRP conjugated | Human | ELISA |
| CSB-RA025833MA1HU | VEGFA Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF |
VEGFA for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA08249A0Rb | Vegfa Antibody | Rat | ELISA, WB, IHC |
VEGFA Proteins
VEGFA Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025833CH CSB-EP025833CH CSB-BP025833CH CSB-MP025833CH CSB-EP025833CH-B |
Recombinant Chicken Vascular endothelial growth factor A (VEGFA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VEGFA Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025833RA CSB-BP025833RA CSB-MP025833RA CSB-EP025833RA-B |
Recombinant Rat Vascular endothelial growth factor A (Vegfa) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP025833RA | Recombinant Rat Vascular endothelial growth factor A (Vegfa) | E.coli |
VEGFA Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025833HU | Recombinant Human Vascular endothelial growth factor A (VEGFA) | Yeast |
| CSB-AP002601HU | Recombinant Human Vascular endothelial growth factor A protein (VEGFA) | E.Coli |
| CSB-AP002591HU | Recombinant Human Vascular endothelial growth factor A protein (VEGFA), partial (Active) | Yeast |
| CSB-MP025833HU(F4)-B | Recombinant Human Vascular endothelial growth factor A (VEGFA),Biotinylated | Mammalian cell |
| CSB-EP025833HU | Recombinant Human Vascular endothelial growth factor A (VEGFA) | E.coli |
| CSB-EP025833HU | Recombinant Human Vascular endothelial growth factor A (VEGFA) | E.coli |
| CSB-EP025833HU1 | Recombinant Human Vascular endothelial growth factor A (VEGFA), partial | E.coli |
| CSB-MP025833HU-WD1 | Recombinant Human Vascular endothelial growth factor A, long form (VEGFA) (Active) | Mammalian cell |
| CSB-MP025833HU-WD2 | Recombinant Human Vascular endothelial growth factor A, long form (VEGFA) (Active) | Mammalian cell |
VEGFA Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025833BO CSB-BP025833BO CSB-MP025833BO CSB-EP025833BO-B |
Recombinant Bovine Vascular endothelial growth factor A (VEGFA) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VEGFA Proteins for Cavia porcellus (Guinea pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025833GU CSB-EP025833GU CSB-BP025833GU CSB-MP025833GU CSB-EP025833GU-B |
Recombinant Guinea pig Vascular endothelial growth factor A (VEGFA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VEGFA Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025833PI CSB-BP025833PI CSB-MP025833PI CSB-EP025833PI-B |
Recombinant Pig Vascular endothelial growth factor A (VEGFA) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP025833PI | Recombinant Pig Vascular endothelial growth factor A (VEGFA) | E.coli |
VEGFA Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025833SH CSB-EP025833SH CSB-BP025833SH CSB-MP025833SH CSB-EP025833SH-B |
Recombinant Sheep Vascular endothelial growth factor A (VEGFA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VEGFA Proteins for Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025833DXJ CSB-EP025833DXJ CSB-BP025833DXJ CSB-MP025833DXJ CSB-EP025833DXJ-B |
Recombinant Coturnix coturnix japonica Vascular endothelial growth factor A (VEGFA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VEGFA Proteins for Mesocricetus auratus (Golden hamster)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025833MRG CSB-EP025833MRG CSB-BP025833MRG CSB-MP025833MRG CSB-EP025833MRG-B |
Recombinant Mesocricetus auratus Vascular endothelial growth factor A (VEGFA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VEGFA Proteins for Equus caballus (Horse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP025833HO CSB-MP025833HO CSB-EP025833HO-B |
Recombinant Horse Vascular endothelial growth factor A (VEGFA) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VEGFA Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025833DO CSB-EP025833DO CSB-BP025833DO CSB-MP025833DO CSB-EP025833DO-B |
Recombinant Dog Vascular endothelial growth factor A (VEGFA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VEGFA ELISA Kit
VEGFA ELISA Kit for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL025833BO | Bovine Vascular endothelial growth factor A(VEGFA) ELISA kit | serum, plasma, tissue homogenates | 11.75 pg/mL |
VEGFA ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11744c | Dog Vascular Endothelial cell Growth Factor,VEGF ELISA KIT | serum, plasma, tissue homogenates | 0.78 pg/mL |
VEGFA ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11718h | Human Vascular Endothelial cell Growth Factor(VEGF) ELISA KIT | serum, plasma, cell culture supernates, tissue homogenates, cell lysates, urine | 25.297 pg/mL |
VEGFA ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04756m | Mouse Vascular Endothelial cell Growth Factor,VEGF ELISA KIT | serum, plasma, cell culture supernates, tissue homogenates | 0.857 pg/mL |
VEGFA ELISA Kit for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12053p | Pig Vascular Endothelial cell Growth Factor,VEGF ELISA KIT | serum, plasma, tissue homogenates | 1.17 pg/mL |
VEGFA ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04757r | Rat Vascular Endothelial cell Growth Factor,VEGF ELISA Kit | serum, plasma, tissue homogenates | 0.97 pg/mL |
