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VEGFA

VEGFA,全稱血管內(nèi)皮生長因子A,是一種重要的蛋白質(zhì),在血管生成和腫瘤生長中發(fā)揮關(guān)鍵作用。它也被稱為血管通透性因子(VPF),能夠促進(jìn)內(nèi)皮細(xì)胞增殖、遷移,并抑制細(xì)胞凋亡,從而增強血管通透性。VEGFA通過與受體VEGFR1和VEGFR2結(jié)合,激活下游信號通路,促進(jìn)血管內(nèi)皮細(xì)胞增殖和遷移,進(jìn)而誘導(dǎo)血管生成。此外,VEGFA還能影響免疫細(xì)胞功能,如抑制樹突細(xì)胞成熟和破壞造血前體細(xì)胞分化,并誘導(dǎo)免疫抑制相關(guān)分子PD-L1的表達(dá),從而影響腫瘤微環(huán)境。
VEGFA與多種疾病密切相關(guān),尤其是腫瘤,如結(jié)直腸癌、非小細(xì)胞肺癌、腦膠質(zhì)瘤等。由于其在腫瘤血管生成中的重要作用,VEGFA已成為重要的藥物靶點。目前,全球首個上市的VEGFA單克隆抗體腫瘤藥物為羅氏開發(fā)的貝伐珠單抗(Avastin),已獲批用于多種腫瘤的治療。此外,還有多種VEGFA抑制劑正在研發(fā)中,如基石藥業(yè)的CS2009,這是一款靶向PD-1、VEGFA和CTLA-4的新型三特異性抗體,展現(xiàn)出良好的抗腫瘤活性。VEGFA相關(guān)藥物的研發(fā)為腫瘤治療提供了新的選擇。

熱銷產(chǎn)品

Recombinant Human Vascular endothelial growth factor A, long form (VEGFA) (Active) (CSB-MP025833HU(F4))

驗證數(shù)據(jù)

CSB-MP025833HU(F4)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP025833HU(F4)

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human VEGFA protein at 2 μg/ml can bind Anti-VEGFA recombinant antibody (CSB-RA025833MA2HU). The EC50 is 0.6797-0.8382 ng/mL.

CSB-MP025833HU(F4)

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human FLT1 (CSB-MP008732HU) protein at 2 μg/ml can bind Human VEGFA protein. The EC50 is 28.72-33.22 ng/mL.

Recombinant Human Vascular endothelial growth factor A (VEGFA) (CSB-EP025833HU)

驗證數(shù)據(jù)

CSB-EP025833HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

VEGFA Recombinant Monoclonal Antibody (CSB-RA025833MA1HU)

驗證數(shù)據(jù)

CSB-RA025833MA1HU

IHC image of CSB-RA025833MA1HU diluted at 1:50 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA025833MA1HU

Immunofluorescence staining of hela cell with CSB-RA025833MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA025833MA1HU

Immunofluorescence staining of MCF7 cell with CSB-RA025833MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

VEGFA Antibodies

VEGFA for Pig

VEGFA for Homo sapiens (Human)

VEGFA for Rattus norvegicus (Rat)

VEGFA Proteins

VEGFA Proteins for Gallus gallus (Chicken)

VEGFA Proteins for Rattus norvegicus (Rat)

VEGFA Proteins for Homo sapiens (Human)

VEGFA Proteins for Bos taurus (Bovine)

VEGFA Proteins for Cavia porcellus (Guinea pig)

VEGFA Proteins for Sus scrofa (Pig)

VEGFA Proteins for Ovis aries (Sheep)

VEGFA Proteins for Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)

VEGFA Proteins for Mesocricetus auratus (Golden hamster)

VEGFA Proteins for Equus caballus (Horse)

VEGFA Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

VEGFA ELISA Kit

VEGFA ELISA Kit for Bos taurus (Bovine)

VEGFA ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)

VEGFA ELISA Kit for Homo sapiens (Human)

VEGFA ELISA Kit for Mus musculus (Mouse)

VEGFA ELISA Kit for Sus scrofa (Pig)

VEGFA ELISA Kit for Rattus norvegicus (Rat)