CISH Antibody
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中文名稱：CISH兔多克隆抗體
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貨號：CSB-PA885721ESR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA885721ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA885721ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CISH Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：BACTS2 antibody; cis 1 antibody; CIS antibody; CIS-1 antibody; CIS1 antibody; Cish antibody; CISH_HUMAN antibody; Cytokine inducible inhibitor of signaling type 1B antibody; Cytokine inducible SH2 containing protein antibody; Cytokine-inducible SH2-containing protein antibody; G18 antibody; Protein G18 antibody; SOCS antibody; Suppressor of cytokine signaling antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Cytokine-inducible SH2-containing protein (1-257AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
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基因功能參考文獻：
- identified P2RX2, KCNQ5, ERBB3 and SOCS3 to be associated with the progression of age-related hearing impairment PMID: 29325454
- CIS interacted with phosphorylated EpoR at Y401, which was critical for the activation of STAT5 and ERK. PMID: 28038963
- Studies indicate that suppressors of cytokine signaling (SOCS) proteins CIS, SOCS1, and SOCS3 can be considered the third immunocheckpoint molecules since they regulate cytokine signals that control the polarization of CD4(+) T cells and the maturation of CD8(+) T cells. PMID: 28188673
- CISH rs414171 and rs6768300 variants might be associated with protection from pulmonary tuberculosis in Zahedan, Southeast Iran. PMID: 27266592
- This study showed that there was significantly increased levels of CIS mRNA in elderly and Alzheimer's disease brains. PMID: 25286386
- Data indicate that CIS protein stability is regulated through multiple mechanisms, including ubiquitination and interaction with Elongin B/C proteins, whereas CIS functional inhibition of PRLR signaling is dependent on the Elongin B/C interaction. PMID: 25448846
- SOCS single nucleotide polymorphism is associated with breast cancer. PMID: 25104439
- Study in Chinese Han population confirms that previously identified variants of CISH are associated with susceptibility to pulmonary tuberculosis. PMID: 25460819
- CISH gene polymorphisms at -292 (rs414171) are associated with HBV clearance in HBeAg-positive CHB patients in the immune active phase, and AA is a favorable genotype for this effect. PMID: 24791876
- Two SNPs (rs414171 and rs2239751) in the CISH gene were associated with persistent HBV infection in Han Chinese population PMID: 24964072
- two genetic variants in CISH gene appear to increase susceptibility to TB in Chinese Han population PMID: 23949851
- CISH promoter rs414171 and rs809451 polymorphisms may play a vital role in mediating individual susceptibility to tuberculosis PMID: 24632804
- methylation of SOCS1, SOCS2, SOCS3 and CISH is infrequent in Ph-ve MPN. PMID: 24131863
- data suggest FXR-mediated upregulation of cytokine inducible SH2-containing protein (CISH) may play an important role in the homeostasis of cytokine signal networks and be beneficial to control cytokine-associated inflammatory diseases PMID: 22817871
- In GH transduction defect, abnormal GH signalling may be caused by over-expression of CIS, which may increase degradation of GHR PMID: 23426819
- Suppressors of both cytokine signaling SOCS7 and cytokine-inducible SH2 protein (CIS) are expressed constitutively at higher levels in LNCaP-S17 (prostate cancer) cells than in LNCaP-C3 cells. PMID: 22213096
- Study indicates the vital role of CISH single nucleotide polymorphism (SNP)-292A>T variant to hepatitis B virus infection in a Vietnamese population. PMID: 22033525
- The authors conclude that Mycobacterium tuberculosis infection induces development of Tregs from CCR4(+) cells through a process that depends on PD-1and CISH. PMID: 21383382
- Variants of CISH are associated with susceptibility to diseases caused by diverse infectious pathogens. PMID: 20484391
- Low level of CISH expression in various tissues suggests that it is a novel prospective marker for diagnosis of colon cancer. PMID: 19807022
- Up-regulation of cytokine inducible SH2-containing protein is associated with adult T-cell leukemia PMID: 14630083
- CIS (cytokine-inducible SH2 protein)is binding with the conserved Y985 and Y1077 motifs in the cytosolic domain of the leptin receptor. PMID: 16684815
- analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor PMID: 17666591
- RACK1 has a role in protecting cancer cells from apoptosis by regulating the degradation of BimEL, which together with CIS could play an important role of drug resistance in chemotherapy PMID: 18420585
- Elongin B/C recruitment regulates substrate binding by CIS PMID: 18508766
- CISH expression in allergen-stimulated CD4(+) T cells from HE-allergic patients was significantly increased in both mRNA and protein levels compared with that from non-HE-allergic children. PMID: 18647318
- CIS can serve as an SLE disease marker and may be involved in the pathogenesis of SLE, and that TNF-alpha may play an important role in the regulation of CIS PMID: 18820827
- miR-98 and let-7 confer cholangiocyte expression of CIS in response to microbial challenge, a process that may be relevant to the regulation of TLR-mediated epithelial innate immune response. PMID: 19592657
- These results suggest that RSV infection escapes the innate antiviral response by inducing SOCS1, SOCS3 or CIS expression in epithelial cells. PMID: 19595407
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組織特異性：Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct.
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